Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes.
Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes.
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DOI：
10.1021/acs.orglett.6b01328
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发表时间：
2016-06
期刊：
影响因子：
5.2
通讯作者：
Zhiyu Xie;Xigong Liu;Lei Liu
中科院分区：
文献类型：
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作者：
Zhiyu Xie;Xigong Liu;Lei Liu
首次报道了以分子氧为末端氧化剂，铜催化的Csp 3-H部分（N-芳基甘氨酸酯）与Csp-H组分（末端炔）的对映选择性交叉偶联反应。这种可持续的方法提供了一种高效且环境友好的方法来快速制备各种光学活性非天然α-氨基酸。
A copper-catalyzed enantioselective cross-coupling of a Csp3-H moiety (N-aryl glycine ester) with a Csp-H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to rapidly prepare a diverse array of optically active non-natural α-amino acids.