The interfollicular epidermal stem cell saga: sensationalism versus reality check
The interfollicular epidermal stem cell saga: sensationalism versus reality check
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DOI：
10.1111/j.1600-0625.2011.01338.x
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发表时间：
2011-09-01
影响因子：
3.6
通讯作者：
Potten, Christopher S.
中科院分区：
文献类型：
--
作者：
Kaur, Pritinder;Potten, Christopher S.
快速更新组织中的成体干细胞已被经典地定义为罕见的、相对静止的细胞，其具有在稳态期间不断自我更新和再生组织的独特能力。虽然这一观点在皮肤领域，特别是在毛囊干细胞生物学领域仍然根深蒂固，但在2007年，它受到了一些著名出版物的挑战。这些论文给读者留下了一种不舒服的感觉，如果一个人认为干细胞和过境放大细胞是两个对立的两极，“永远不会相遇。”“即使你不同意这种极端的观点，其影响似乎是深远的，因为大多数用于干细胞鉴定的技术都使用了增殖区室由两个不同的、相互排斥的区室组成的基本原则，即一小部分具有无限自我更新的长寿静止干细胞和大量快速循环的干细胞，在正常稳态条件下自我更新能力有限或没有自我更新能力的短暂瞬时扩增细胞。然而，这些最近的发现导致了可以被描述为耸人听闻的论文，因为他们很少或根本没有尝试将他们的观察结果与大量的历史数据相协调，这些数据直接关系到正常稳态条件下干细胞活性的解释。在这里，我们提供了一些解释，可能有助于整合所有的数据，同时提出了一个案例，即静止干细胞和循环的“过境放大”细胞有助于表皮替代。
Adult stern cells in rapidly renewing tissues have been classically defined as rare, relatively quiescent cells with the unique capacity to constantly self-renew and regenerate tissues during homeostasis. Although this view remains firmly embedded in the skin field, particularly in the area of hair follicle stem cell biology, it has been challenged by a number of notable publications in 2007. These papers leave an uncomfortable feeling with the reader if one believes that stem cells and transit amplifying cells are two polar opposites and 'never the twain shall meet.' Even if you do not subscribe to this extreme view, the implications appear to be far-reaching given that the majority of techniques devised for stem cell identification have used the fundamental tenet that the proliferating compartment is comprised of two distinct, mutually exclusive compartments, i.e. a minor proportion of long-lived quiescent stem cells with unlimited self-renewal and a large pool of rapidly cycling, short-lived transient amplifying cells with limited or no self-renewal capacity in normal steady-state conditions. However, these recent findings have resulted in papers that could be described as sensationalistic because they make little or no attempt to reconcile their observations with the large bulk of historical data with direct bearing on the interpretation of stem cell activity in normal steady-state conditions. Here, we offer some explanations that may help to integrate all of the data while presenting a case that both quiescent stem cells and cycling 'transit amplifying' cells contribute to epidermal replacement.