Venous thromboembolism in patients with diffuse large B-cell lymphoma
Venous thromboembolism in patients with diffuse large B-cell lymphoma
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DOI：
10.1080/10428190600560991
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发表时间：
2006-06-01
影响因子：
2.6
通讯作者：
Francis, Charles W.
中科院分区：
文献类型：
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作者：
Komrokji, Rami S.;Uppal, Nikhil P.;Francis, Charles W.
我们进行了一项回顾性记录回顾，以确定弥漫性大B细胞淋巴瘤(DLBCL)患者静脉血栓栓塞症(VTE)的发生率。回顾了1990年至2001年在三级护理医院诊断为DLBCL的所有患者的记录。排除由低度恶性淋巴瘤、中枢神经系统淋巴瘤、HIV相关淋巴瘤或病历不全转化而来的患者。所有由影像研究证实的症状性静脉血栓栓塞症，无论是在诊断时出现，还是在最初的治疗中发生，都被识别出来。211例患者中有27例发生VTE(12.8%)。I期疾病与低风险相关，而国际预后指数得分高则增加风险。在VTE患者中，37%的患者在确诊时出现血栓，22%的患者在第一个化疗周期中出现血栓，82%的患者在前三个周期中出现血栓。发生静脉血栓栓塞者的中位生存期为1.04年[95%可信区间为0.75~1.33]，而非静脉血栓栓塞者的中位生存期为5.2年(95%可信区间1.8~8.6)(P=0.038)。我们认为，VTE是DLBCL的常见并发症，尤其是在诊断和治疗期间，它与较差的预后有关。
We conducted a retrospective record review to determine the frequency of venous thromboembolism (VTE) in patients with diffuse large B-cell lymphoma (DLBCL). All records from 1990 to 2001 of patients with the diagnosis of DLBCL at a tertiary care hospital were reviewed. Those with transformation from low-grade lymphoma, central nervous system lymphoma, HIV-related lymphoma or with incomplete records were excluded. All episodes of symptomatic VTE confirmed by imaging studies that were either present at diagnosis or occurred during initial treatment were identified. VTE occurred in 27 of 211 patients (12.8%). Stage I disease was associated with a low risk, whereas a high international prognostic index score increased risk. Of patients with VTE, thrombosis was present at diagnosis in 37% and occurred during the first chemotherapy cycle in 22% and during the first three cycles in 82%. The median survival of patients with VTE was 1.04 years [95% confidence interval (CI)=0.75-1.33] compared to 5.2 years (95% CI 1.8-8.6) for those without VTE (P=0.038). We conclude that VTE is a frequent complication of DLBCL that occurs particularly at diagnosis and during initial therapy, and it is associated with a worse prognosis.