Low-frequency fatigue
Low-frequency fatigue
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DOI：
10.1093/ptj/86.8.1146
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发表时间：
2006-08-01
期刊：
影响因子：
3.2
通讯作者：
Binder-Macleod, Stuart A.
中科院分区：
文献类型：
--
作者：
Keeton, R. Benjamin;Binder-Macleod, Stuart A.
肌肉疲劳被定义为由于最近的肌肉收缩而导致的力量或扭矩产生能力的暂时丧失。1肌肉疲劳的机制很多，可能起源于从中枢神经系统(CNS)到细胞水平的跨桥自行车。2、3提出的疲劳产生的主要机制是：(1)运动神经元兴奋不足，(2)动作电位沿轴突分支点传递不良，(3)动作电位未能侵入突触突触或未能触发肌神经接头处的递质释放，(4)连接后膜未能充分去极化，(5)动作电位未能传播到整个肌膜或动作电位的幅度太低，(6)动作电位不能侵入T管系统和肌浆网系统或动作电位不能触发钙释放；(7)肌肉收缩系统；(8)线粒体，表示维持收缩的代谢事件。2直到最近，肌肉疲劳被认为是由于无氧代谢过程中肌肉中乳酸积累或由于氢离子浓度([H+])上升而导致肌肉内pH降低所致。4-6然而，最近的文献表明，在跨桥水平，[H+]可能不是肌肉疲劳的主要原因。另一方面，无机磷的积累被认为是肌肉疲劳的一个重要原因，可能是因为它在跨桥水平上所起的作用。7、19-21
Muscle fatigue has been defined as a temporary loss in force or torque-generating ability due to recent muscle contraction. 1 The mechanisms underlying muscle fatigue are numerous and may have their origins anywhere from the central nervous system (CNS) to cellular-level cross-bridge cycling. 2, 3 The major proposed mechanisms of fatigue production are:(1) inadequate excitation of motoneurons,(2) poor action potential transmission along axonal branch points,(3) failure of the action potential to invade the synaptic bouton or failure to trigger transmitter release at the myoneural junction,(4) failure of the post-junctional membrane to be depolarized adequately,(5) failure of the action potential to propagate the full length of the sarcolemma or the action potential has too low of an amplitude,(6) failure of the action potential to invade the T-tubule system and sarcoplasmic reticulum system or failure of the action potential to trigger calcium release,(7) contractile system of the muscle, and (8) mitochondria, signifying metabolic events that sustain contraction. 2Until recently, muscle fatigue was thought to be caused by lactic acid accumulation or a lowered pH within the muscle due to a rising hydrogen ion concentration ([H+]) during anaerobic metabolism. 4–6 Recent literature, however, has shown that at the cross-bridge level,[H+] may not be a major causative factor of muscle fatigue. 7–18 Inorganic phosphate accumulation, on the other hand, has been implicated as a significant cause of muscle fatigue, presumably in its role at the cross-bridge level. 7, 19–21