Cytosolic pH: A conserved regulator of cell growth?
Cytosolic pH: A conserved regulator of cell growth?
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DOI：
10.4161/23723548.2014.969643
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发表时间：
2014-01-01
影响因子：
2.1
通讯作者：
Peter, Matthias
中科院分区：
文献类型：
--
作者：
Dechant, Reinhard;Peter, Matthias
尽管雷帕霉素靶标 (TOR) 激酶和 Ras 是酵母和哺乳动物细胞生长的中心调节因子，但其受营养物质调节的分子机制仍知之甚少。有趣的是，最近的研究发现胞质 pH 值是这两种途径的关键调节信号，这可能对肿瘤细胞生物学产生广泛的影响
Although target of rapamycin (TOR) kinase and Ras are central regulators of cell growth in yeast and mammals, the molecular mechanisms underlying their regulation by nutrients are still poorly understood. Interestingly, recent studies identified cytosolic pH as a critical regulatory signal for both pathways, which might have widespread implications for tumor cell biology