Cortactin in Lung Cell Function and Disease.
Cortactin in Lung Cell Function and Disease.
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DOI：
10.3390/ijms23094606
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发表时间：
2022-04-21
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
皮质蛋白（CTTN）是一种肌动蛋白结合和细胞骨架蛋白，在大多数细胞类型的细胞皮质和其他外周结构中大量存在。它最初被描述为在CTTN内的几个酪氨酸位点处Src介导的磷酸化的靶标，并且这些酪氨酸位点处的翻译后修饰是其功能的主要调节剂。CTTN参与需要细胞骨架重排的多种细胞功能，包括板状伪足形成、细胞迁移、侵袭和依赖于所涉及的细胞类型的各种其他过程。CTTN在血管内皮细胞中的作用对于促进屏障完整性和抑制血管通透性和组织水肿特别重要。为了介导其功能效应，CTTN经历了多种翻译后修饰，并与许多其他蛋白质相互作用以改变细胞骨架结构和信号传导机制。在本综述中，我们简要介绍了CTTN的结构，翻译后修饰和蛋白质结合伙伴，然后专注于其在调节细胞过程和完善的功能机制，主要是在血管内皮细胞和疾病模型中的作用。然后，我们提供了CTTN功能如何影响多种肺部疾病，包括急性肺损伤综合征，COPD和哮喘的病理生理学的见解。
Cortactin (CTTN) is an actin-binding and cytoskeletal protein that is found in abundance in the cell cortex and other peripheral structures of most cell types. It was initially described as a target for Src-mediated phosphorylation at several tyrosine sites within CTTN, and post-translational modifications at these tyrosine sites are a primary regulator of its function. CTTN participates in multiple cellular functions that require cytoskeletal rearrangement, including lamellipodia formation, cell migration, invasion, and various other processes dependent upon the cell type involved. The role of CTTN in vascular endothelial cells is particularly important for promoting barrier integrity and inhibiting vascular permeability and tissue edema. To mediate its functional effects, CTTN undergoes multiple post-translational modifications and interacts with numerous other proteins to alter cytoskeletal structures and signaling mechanisms. In the present review, we briefly describe CTTN structure, post-translational modifications, and protein binding partners and then focus on its role in regulating cellular processes and well-established functional mechanisms, primarily in vascular endothelial cells and disease models. We then provide insights into how CTTN function affects the pathophysiology of multiple lung disorders, including acute lung injury syndromes, COPD, and asthma.
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影响因子：
1.7
作者：
D'Anna, Claudia;Cigna, Diego;Pace, Elisabetta
通讯作者：
Pace, Elisabetta
影响因子：
--
作者：
Belvitch P;Htwe YM;Brown ME;Dudek S
通讯作者：
Dudek S
影响因子：
3.1
作者：
Brown M;Adyshev D;Bindokas V;Moitra J;Garcia JG;Dudek SM
通讯作者：
Dudek SM
DOI：
10.1152/ajplung.00466.2001
发表时间：
2003-06-01
影响因子：
4.9
作者：
Carnevali, S;Petruzzelli, S;Giuntini, C
通讯作者：
Giuntini, C
影响因子：
3.4
作者：
Arce, Fernando Teran;Whitlock, Jenny L.;Dudek, Steven M.
通讯作者：
Dudek, Steven M.