Age-specific patterns of unsatisfactory results for conventional Pap smears and liquid-based cytology: data from two randomised clinical trials
Age-specific patterns of unsatisfactory results for conventional Pap smears and liquid-based cytology: data from two randomised clinical trials
复制标题
DOI：
10.1111/j.1471-0528.2010.02650.x
复制
发表时间：
2010-08-01
影响因子：
5.8
通讯作者：
Arbyn, M.
中科院分区：
文献类型：
--
作者：
Castle, P. E.;Bulten, J.;Arbyn, M.
目的按年龄调查液基细胞学（LBC）与传统细胞学（CC）的宫颈细胞样本不满意率。设计随机临床试验。设置在荷兰和意大利进行基于人群的宫颈癌筛查。人群受邀参加筛查的无症状女性参加两项随机试验：荷兰 ThinPrep（R）与传统细胞学（NETHCON；39 010 CC、46 064 LBC）和新宫颈癌筛查技术 (NTCC; 22 771 CC, 22 403 LBC)。方法使用皮尔逊卡方检验、逻辑回归和趋势检验比较分类变量。主要结果指标不满意样本的比例、LBC 与 CC 的比率以及 5 年组的变化。结果在 NETHCON 中，与CC 样本（0.33 与 1.11%）。传统细胞学按年龄组划分的不满意结果没有显着趋势（P（趋势） = 0.54），但 LBC 的不满意结果百分比有随着年龄增加而增加的趋势（P（趋势） < 0.001）。在 NTCC 中，与传统细胞学检查相比，被判定为不合格的 LBC 样本比例较低（2.59% 对 4.10%）。按年龄组划分，常规细胞学检查（P（趋势）< 0.001）和LBC（P（趋势）= 0.01）的不满意结果有所减少，尽管后者的趋势出现在55-60岁年龄组（排除该组时，P（趋势）= 0.62）。结论收集结果的临床试验和使用的细胞学方法是最重要的决定因素细胞学检查结果不令人满意。在所有情况下，与 CC 相比，LBC 中不合格样本的比例较低。年龄的影响取决于用于定义不满意结果的标准。
ObjectiveTo investigate the rate of unsatisfactory cervical cell samples in liquid-based cytology (LBC) versus conventional cytology (CC) by age.DesignRandomised clinical trials.SettingPopulation-based cervical cancer screening in the Netherlands and Italy.PopulationAsymptomatic women invited for screening enrolled in two randomised trials: Netherlands ThinPrep (R) versus conventional cytology (NETHCON; 39 010 CC, 46 064 LBC) and New Technologies in Cervical Cancer Screening (NTCC; 22 771 CC, 22 403 LBC).MethodsComparison of categorical variables using Pearson's chi-square test, logistic regression and trend tests.Main outcome measuresProportion of unsatisfactory samples, ratio of LBC versus CC, and variation by 5-year group.ResultsIn NETHCON, a lower percentage of LBC samples were judged to be unsatisfactory compared with CC samples (0.33 versus 1.11%). There was no significant trend in unsatisfactory results by age group for conventional cytology (P(trend) = 0.54), but there was a trend towards an increasing percentage of unsatisfactory results with increasing age for LBC (P(trend) < 0.001). In NTCC, a lower percentage of LBC samples were judged to be unsatisfactory compared with conventional cytology (2.59 versus 4.10%). There was a decrease in the unsatisfactory results by age group with conventional cytology (P(trend) < 0.001) and with LBC (P(trend) = 0.01), although the latter trend arose from the 55-60-years age group (P(trend) = 0.62 when excluding this group).ConclusionsThe clinical trial in which the results were collected and the cytologic method used were the most important determinants of unsatisfactory cytology. In all situations, the proportion of unsatisfactory samples was lower in LBC compared with CC. The effects of age depended on the criteria used to define unsatisfactory results.