Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels

Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels
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DOI:
10.1002/adma.201303387
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发表时间:
2014
期刊:
影响因子:
29.4
通讯作者:
Yu Zhao;Tasuku Nakajima;Jing Jing Yang-Jing;T. Kurokawa;J. Liu;Jishun Lu;Shuji Mizumoto;K. Sugahara-
Yu Zhao;Tasuku Nakajima;Jing Jing Yang-Jing;T. Kurokawa;J. Liu;Jishun Lu;Shuji Mizumoto;K. Sugahara-
中科院分区:
材料科学1区
文献类型:
--
作者:
Yu Zhao;Tasuku Nakajima;Jing Jing Yang-Jing;T. Kurokawa;J. Liu;Jishun Lu;Shuji Mizumoto;K. Sugahara-

文献摘要

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基于分子支架的概念,由蛋白多糖聚合体的组成成分--硫酸软骨素蛋白多糖(1)、硫酸软骨素(2)和透明质酸钠(3)--与中性生物相容性聚合物相结合,成功地开发了一系列坚韧的双网络水凝胶(ST-DN凝胶)。这项工作展示了一种很有前途的方法来创造生物聚合物为基础的坚韧水凝胶的生物医学应用。
Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from the components of proteoglycan aggregates - chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) - are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer-based tough hydrogels for biomedical applications.