There are no differences in brachial artery endothelial shear stress and blood flow patterns between males and females during exercise
There are no differences in brachial artery endothelial shear stress and blood flow patterns between males and females during exercise
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DOI：
10.1111/cpf.12722
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发表时间：
2021-07-26
影响因子：
1.8
通讯作者：
Morales-Acuna, Francisco
中科院分区：
文献类型：
--
作者：
Gurovich, Alvaro N.;Rodriguez, Lisa;Morales-Acuna, Francisco
绝经前的女性患心血管疾病的风险比男性低。运动诱导的内皮细胞切应力(ESS)和血流模式的性别差异可能解释了这种风险降低的部分原因。这项横断面研究的目的是确定男性和女性在臂动脉运动诱发的ESS和血流模式方面的差异。受试者30人(女性13人)，根据血乳酸水平(即4·0 mm o l/L)进行三负荷稳态运动试验。分别使用沃姆斯利近似值和雷诺数估计静息状态和每次工作时的ESS和血流模式。男性和女性的顺行和逆行ESS均表现出运动强度依赖性的增加。顺行刺激(F-(1，F-30)=0.715，p=0.405，F-(1中心点672，F-60)=1.511，p=0.232)和逆行刺激(F-(1，F-30)=0.794，p=0.380，F-(1中心点810，F-60)=1.022，p=0.361)无明显的性别效应或交互作用。此外，在所有的运动中，两组的顺行血流都是湍流的，而在中等强度和高强度的运动中，逆行血流受到干扰。当运动负荷相同时，男性和女性在运动诱发的ESS和血流模式上没有差异。这表明，从血流动力学的角度来看，运动训练对血管的益处在两性中是相似的。
Premenopausal females have a lower cardiovascular risk than males. Sex differences on exercise-induced endothelial shear stress (ESS) and blood flow patterns may explain part of this risk reduction. The purpose of this cross-sectional study was to determine the differences in brachial artery exercise-induced ESS and blood flow patterns between males and females. Thirty subjects (13 females) were recruited to perform a three-workload steady-state exercise test based on blood lactate levels (i.e. 4.0 mmol/l). ESS and blood flow patterns were estimated at rest and during each workload using Womersley's approximation and Reynolds number, respectively. Both males and females showed an exercise intensity-dependent increase in antegrade and retrograde ESS. There was no significant sex effect or interaction for antegrade ESS (F-(1,F- 30) = 0.715, p = 0.405 and F-(1 center dot 672,F- 60) = 1.511, p = 0.232, respectively) or retrograde ESS (F-(1,F- 30) = 0.794, p = 0.380 and F-(1 center dot 810,F- 60) = 1.022, p = 0.361, respectively). Additionally, antegrade blood flow was turbulent during all bouts of exercise while retrograde blood flow became disturbed at moderate and high exercise intensities in both groups. There are no differences in exercise-induced ESS and blood flow patterns between males and females when the exercise load is equivalent. This suggests that the vascular benefits of exercise training are similar in both sexes from a haemodynamic standpoint.