THE SEPSIS SYNDROME IN A DUTCH UNIVERSITY HOSPITAL - CLINICAL OBSERVATIONS
THE SEPSIS SYNDROME IN A DUTCH UNIVERSITY HOSPITAL - CLINICAL OBSERVATIONS
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DOI：
10.1001/archinte.153.19.2241
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发表时间：
1993-10-11
影响因子：
--
通讯作者：
VERHOEF, J
中科院分区：
文献类型：
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作者：
KIEFT, H;HOEPELMAN, AIM;VERHOEF, J
背景：大多数脓毒症综合征病因的研究集中在重症监护病房住院患者。在本研究中，我们分析了所有住院患者脓毒症综合征的发生率、原因和转归。方法：对382例（占全部住院患者的5.6%）患者进行采血培养，获得临床及微生物学资料。结果：脓毒症综合征发生率为13.6 / 1000（1.06 / 1000住院日），感染性休克发生率为4.6 / 1000。呼吸道为主要感染部位。在所有脓毒症综合征患者中，38% （n=35）血培养阳性。这些培养中有一半以上（13例[57%]）是由革兰氏阳性微生物引起的（不包括接受选择性消化道净化和血管内器械相关菌血症的患者）。脓毒症综合征无休克患者的死亡率为28%(17/61)，而脓毒症休克患者的死亡率为55%（17/31）。有心血管疾病的患者有明显的(P
Background: Most studies of the cause of sepsis syndrome focus on patients hospitalized in intensive care units. In this study, we analyzed the incidence, cause, and outcome of the sepsis syndrome in all hospitalized patients.Methods: Clinical and microbiologic data were obtained for 382 patients (5.6% of all patients admitted) from whom blood was drawn for culture.Results: The incidence of the sepsis syndrome was 13.6 per 1000 patients admitted (1.06 per 1000 hospital days), while the incidence of septic shock was 4.6 per 1000. The respiratory tract was the predominant infection site. Of all patients with sepsis syndrome, 38% (n=35) had positive blood cultures. More than half of these cultures (13 [57%]) were caused by gram-positive microorganisms (excluding patients receiving selective decontamination of the digestive tract and those with intravascular device-related bacteremias). The mortality for patients with sepsis syndrome without shock was 28% (17/61), while for patients with septic shock, it was 55% (17/31). Patients with cardiovascular diseases had a significantly (P