PARKINSON SUBTYPE-SPECIFIC GRANGER-CAUSAL COUPLING AND COHERENCE FREQUENCY IN THE SUBTHALAMIC AREA
PARKINSON SUBTYPE-SPECIFIC GRANGER-CAUSAL COUPLING AND COHERENCE FREQUENCY IN THE SUBTHALAMIC AREA
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DOI：
10.1016/j.neuroscience.2016.06.052
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发表时间：
2016-09-22
期刊：
影响因子：
3.3
通讯作者：
Timmermann, Lars
中科院分区：
文献类型：
--
作者：
Florin, Esther;Pfeifer, Johannes;Timmermann, Lars
先前对帕金森氏病(PD)的研究表明，在受影响的手臂肌肉活动和丘脑底核(STN)内的电生理活动之间存在主要的传入耦合。到目前为止，还没有关于PD患者中哪些频率成分驱动传入信息流的信息。非定向耦合，例如通过测量相干性，主要建立在β频段以及颤动频率上。根据以前的证据，这种疾病的不同亚型很可能与不同的连接模式有关。因此，我们确定了18例僵硬(AR)PD患者和8例震颤显性(TD)PD患者STN的局部场电位(LFP)和对侧手臂表面肌电(EMG)之间的一致性和因果关系。在术中记录期间，患者被要求将前臂抬起至记录侧的对侧。在震颤期和非震颤期的组合以及仅震颤期的TD患者中，检测到明显更多的传入连接。在STN内，分别有74%和63%的传入连接与4-8赫兹和8-12赫兹的连贯有关。然而，当只考虑震颤时--传入时间明显多于传出时间--在所有记录高度上，连接与12至20赫兹的一致性有关。在所有记录高度的4至12赫兹的频率范围内，传出和传出连接之间没有差别。对于AR患者，不同频段的STN内传入和传出联系没有显著差异。尽管如此，对于AR患者来说，STN背侧的传入连接明显多于传出连接，与12至16赫兹频率范围内的一致性有关。这些结果为AR和TD帕金森患者存在不同的病理振荡和通路提供了进一步的证据。(C)2016年IBRO。爱思唯尔有限公司出版。保留所有权利。
Previous work on Parkinson's disease (PD) has indicated a predominantly afferent coupling between affected arm muscle activity and electrophysiological activity within the subthalamic nucleus (STN). So far, no information is available indicating which frequency components drive the afferent information flow in PD patients. Non-directional coupling e.g. by measuring coherence is primarily established in the beta band as well as at tremor frequency. Based on previous evidence it is likely that different subtypes of the disease are associated with different connectivity patterns. Therefore, we determined coherence and causality between local field potentials (LFPs) in the STN and surface electromyograms (EMGs) from the contralateral arm in 18 akinetic-rigid (AR) PD patients and 8 tremor-dominant (TD) PD patients. During the intraoperative recording, patients were asked to lift their forearm contralateral to the recording side. Significantly more afferent connections were detected for the TD patients for tremor periods and non-tremor-periods combined as well as for only tremor periods. Within the STN 74% and 63% of the afferent connections are associated with coherence from 4-8 Hz and 8-12 Hz, respectively. However, when considering only tremor-periods significantly more afferent than efferent connections were associated with coherence from 12 to 20 Hz across all recording heights. No difference between efferent and afferent connections is seen in the frequency range from 4 to 12 Hz for all recording heights. For the AR patients, no significant difference in afferent and efferent connections within the STN was found for the different frequency bands. Still, for the AR patients dorsal of the STN significantly more afferent than efferent connections were associated with coherence in the frequency range from 12 to 16 Hz. These results provide further evidence for the differential pathological oscillations and pathways present in AR and TD Parkinson patients. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.