POSTSYNAPTIC CONTROL OF PLASTICITY IN DEVELOPING SOMATOSENSORY CORTEX
POSTSYNAPTIC CONTROL OF PLASTICITY IN DEVELOPING SOMATOSENSORY CORTEX
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DOI：
10.1038/364623a0
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发表时间：
1993-08-12
期刊：
影响因子：
64.8
通讯作者：
OLEARY, DDM
中科院分区：
文献类型：
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作者：
SCHLAGGAR, BL;FOX, K;OLEARY, DDM
正常和剥夺发育过程中突触连接的重新排列被认为是由传入冲动活动的相关性控制的。一种受欢迎的模型是基于同步活动传入的突触后检测。当突触前和突触后活动相关时，突触会稳定；当其活动不相关时，突触会减弱或消除2,3。该模型的大多数证据来自证明，相关传入输入对于发育中的脊椎动物视觉系统中眼睛主导输入的分离是必要的1,4,5，并且猫视觉皮层中眼睛优势柱的关键期可塑性因突触后传递的阻断而被破坏6-8。我们测试了啮齿动物初级体感皮层 (S1)9-13 中被称为“桶”的体感柱的发育可塑性是否与眼优势柱的发育可塑性相似。我们在这里报告，通过应用谷氨酸受体拮抗剂选择性破坏大鼠 S1 的突触后激活，抑制了关键时期由感觉周围操作引起的丘脑皮质传入神经体位模式的重排。这些发现表明，突触后激活在 S1 皮层关键期可塑性中发挥着重要作用。
THE rearrangement of synaptic connections during normal and deprived development is thought to be controlled by correlations in afferent impulse activity1. A favoured model is based on postsynaptic detection of synchronously active afferents; synapses are stabilized when pre- and postsynaptic activity is correlated and weakened or eliminated when their activity is uncorrelated2,3. Most evidence for this model comes from demonstrations that correlated afferent input is necessary for the segregation of eye-dominant inputs in the developing vertebrate visual system1,4,5 and that critical period plasticity of ocular dominance columns in cat visual cortex is disrupted by blockade of postsynaptic transmission6-8. We tested whether the developmental plasticity of somatosensory columns, known as 'barrels', in rodent primary somatosensory cortex (S1)9-13 is similar to that of ocular dominance columns. We report here that the selective disruption of postsynaptic activation in rat S1 by application of a glutamate receptor antagonist inhibits rearrangements in the somatotopic patterning of thalamocortical afferents induced by manipulations of the sensory periphery during the critical period. These findings show that postsynaptic activation has a prominent role in critical period plasticity in S1 cortex.