What is the Effect of Motor Level Peripheral Electrical Stimulation on Corticospinal Excitability and Functional Outcome Measures in Both Healthy Participants and those with Neurological Disorders? A Systematic Review and Meta-Analysis
What is the Effect of Motor Level Peripheral Electrical Stimulation on Corticospinal Excitability and Functional Outcome Measures in Both Healthy Participants and those with Neurological Disorders? A Systematic Review and Meta-Analysis
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运动水平外周电刺激对健康参与者和患有神经系统疾病的参与者的皮质脊髓兴奋性和功能结果测量有什么影响？
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
M. Zoghi
中科院分区：
文献类型：
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作者：
S. Jaberzadeh;D. Mezhov;M. Zoghi
简介：探讨运动水平外周刺激（MLS）对健康受试者和神经系统疾病受试者的皮质脊髓兴奋性（CSE）的影响，并建立最适合此目的的刺激参数。方法和材料：一个全面的搜索策略，确定回答审查问题的论文。确定的研究用于进行荟萃分析。结果：运动水平刺激后，CSE较基线有显著变化：57.66%（95%CI）。亚组分析显示，100 Hz亚组：68.31%（95%CI）和20- 50 Hz亚组：80.14%（95%CI）有显著变化，但30 min无显著变化：53.14%（95%CI）。CSE在“无刺激”后无显著变化：69.61%（95%CI）。结论：研究结果表明，MLS导致CSE增加;然而，变化幅度取决于刺激频率和刺激面积。此外，刺激持续时间超过30分钟不会导致更大的变化。重要性：本综述文章希望催化进一步的研究，以确定适当的MLS治疗参数的特定肌肉群。关键词：运动水平刺激、皮质脊髓兴奋性、功能性电刺激、联合刺激、经颅磁刺激、运动诱发电位
Introduction: To explore the effect of Motor Level peripheral Stimulation (MLS) on Corticospinal Excitability (CSE) in healthy participants and those with neurological disorders, and to establish stimulation parameters best suited to this purpose. Methods and Materials : A comprehensive search strategy was developed for identification of papers answering the review question. The studies identified were used to do meta-analyses. Results: Following motor-level stimulation, there was a significant change in CSE from baseline: 57.66% (95% CI). Subgroup analysis showed that there was a significant change in the 100Hz subgroup: 68.31% (95% CI) and the 20-50Hz subgroup: 80.14% (95% CI), but not in the 30mins: 53.14% (95% CI). CSE showed no significant changes following ‘no stimulation”: 69.61% (95% CI). Conclusions: The findings indicate that MLS leads to increases in CSE; however, magnitude of change depends on the stimulation frequency and the area stimulated. It also appears that stimulation durations of longer than 30mins do not result in greater changes. Significance: The present review article hopes to catalyze further research into the determination of appropriate MLS treatment parameters for specific muscle groups. Key words: Motor level stimulation, corticospinal excitability, functional electrical stimulation, associative stimulation, transcranial magnetic stimulation, motor evoked potentials