Reactions between activated benzo(a)pyrene and nucleophilic compounds, with possible implications on the mechanism of tumor initiation.
Reactions between activated benzo(a)pyrene and nucleophilic compounds, with possible implications on the mechanism of tumor initiation.
复制标题
活化的苯并（a）芘和亲核化合物之间的反应，可能对肿瘤发生机制产生影响。
DOI：
10.1093/jnci/53.2.393
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
R. Auerbach
中科院分区：
文献类型：
--
作者：
E. Cavalieri;R. Auerbach
Benzo[a]pyrene activated by one-electron oxidation with iodine or ferric ion (an essential component of cytochrome P-450), or by a presumed electrophilic oxygen obtained from the model system ferric chloride and hydrogen peroxide produced cationic species which on subsequent trapping with suitable nucleophiles gave only 6-substituted benzopyrenes. The results implied an appreciable degree of positive-charge localization at the 6-carbon atom in the reactive intermediates of the carcinogenic compound.
