Chromatid gaps as a marker of mutagenic effect of environmental pollution in commensal and wild rodents of the Ural mountains.
Chromatid gaps as a marker of mutagenic effect of environmental pollution in commensal and wild rodents of the Ural mountains.
复制标题
染色单体缺口作为乌拉尔山脉共生和野生啮齿动物环境污染致突变效应的标志。
作者：
Gileva Ea
人们很早就认为，无色间隙可以作为环境污染致突变效应的标志，特别是在致染色体断裂作用较弱的情况下。本文报道了在不同环境致突变性的乌拉尔地区家鼠和普通田鼠的染色体真畸变率和染色单体裂隙率。根据CBIS系统区分间隙和断裂。在几个地方，啮齿类动物表现出高度显着增加的细胞与染色体畸变和间隙与基线值相比，只有在普通田鼠，P值为0.056的差距差距增加。平均间隙率与染色体畸变率显著相关，不仅与染色单体断裂相关，而且与其他类型的畸变也相关。该参数似乎不是比真正的染色体突变更敏感的环境诱变剂的指标，当诱变的影响不是很强大，因为它是在调查的地方。家鼠可作为生态遗传监测的有效试验种。
It was supposed earlier that achromatic gaps could be used as markers of mutagenic effect of environmental pollution, especially under weaker clastogenic influences. The frequencies of true chromosome aberrations and those of chromatid gaps were estimated in house mice and common voles from Uralian localities with various mutagenic potential of environment. Gaps and breaks were distinguished according to the CBIS system. In several localities, rodents displayed highly significant increase of the rates of cells with chromosome aberrations and with gaps as compared to the baseline values; only in the common vole, the P level for the gap increase was 0.056. The mean gap rate was correlated significantly with that of chromosome aberrations, not only with chromatid breaks, but with the aberrations of other types, too. This parameter appears not to be more sensitive indicator of environmental mutagens than true chromosome mutations, when mutagenic impact is not very powerful, as it was in the localities investigated. The house mouse can be recommended as an effective test species for ecogenetic monitoring.