Measurement of startle response, prepulse inhibition, and habituation.
Measurement of startle response, prepulse inhibition, and habituation.
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DOI：
10.1002/0471142301.ns0807s03
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发表时间：
2001-05-01
影响因子：
--
通讯作者：
Swerdlow, N R
中科院分区：
文献类型：
--
作者：
Geyer, M A;Swerdlow, N R
惊吓反应由突然的、相对强烈的刺激引起的一系列反射组成。惊吓反射可用于研究神经功能的基本特性，从脑桥和网状结构内的神经生理学和解剖学关系到复杂行为状态和认知过程的前脑调节。该单元提出了测量大鼠对声刺激的惊吓反应的方案，以及包括实验操作（例如药物治疗和惊吓习惯测量）的修改；一种测量惊吓前脉冲抑制（PPI）的方法；以及专门的大鼠处理和镇静技术，以补充惊吓方案。
The startle response is comprised of a constellation of reflexes elicited by sudden, relatively intense stimuli. The startle reflex is useful for studying fundamental properties of nervous function ranging from neurophysiological and anatomical relationships within the pons and reticular formation to forebrain regulation of complex behavioral states and cognitive processes. This unit presents protocols for measurement of the startle response in rats to acoustic stimuli, along with modifications encompassing an experimental manipulation such as drug treatment and measures of habituation of startle; a method for measuring prepulse inhibition (PPI) of startle; and specialized rat handling and calming techniques that supplement the startle protocols.