Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala
Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala
复制标题
DOI：
10.1016/0920-1211(95)00093-3
复制
发表时间：
1996-05-01
影响因子：
2.2
通讯作者：
Halonen, T
中科院分区：
文献类型：
--
作者：
Pitkanen, A;Tuunanen, J;Halonen, T
本研究比较了卡马西平(20 mg/kg/d)和维甲酸(250 mg/kg/d)对癫痫持续状态大鼠穿支通路刺激模型中海马和杏仁核损伤的保护作用。其中一组大鼠接受了药物的组合。药物治疗在刺激前一周开始，此后持续两周。采用Galyas银染和生长抑素免疫组织化学方法检测神经元损伤情况。在减少电刺激期间癫痫发作的次数和严重程度方面，所有药物治疗都同样有效。Vigabatrin组大鼠肺门生长抑素免疫反应阳性(SOM-ir)神经元和海马CA3c区锥体细胞的损伤程度轻于模型组(SOM-ir，P
The present study compares the efficacy of carbamazepine (20 mg/kg/day) and vigabatrin (250 mg/kg/day) in preventing hippocampal and amygdaloid damage in the perforant pathway stimulation model of status epilepticus in the rat. One group of rats received a combination of the drugs. Drug treatments were started one week before the stimulation and continued for two weeks thereafter. Gallyas silver impregnation and somatostatin immunohistochemistry were used to detect neuronal damage. All drug treatments were equally effective in decreasing the number and severity of seizures during electrical stimulation. In the vigabatrin group, the damage to the hilar somatostatin-immunoreactive (SOM-ir) neurons and hippocampal CA3c pyramidal cells was less severe than in the vehicle (SOM-ir, P