Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors
Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors
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DOI：
10.1021/acs.orglett.6b03336
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发表时间：
2017-01-06
期刊：
影响因子：
5.2
通讯作者：
Chakrapani, Harinath
中科院分区：
文献类型：
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作者：
Chauhan, Preeti;Bora, Prerona;Chakrapani, Harinath
硫化氢(H2S)是许多细胞过程的介体，调节细胞内这种气体的水平已成为一个重要的治疗领域。因此，局部产生硫化氢是非常有用的，但也具有极大的挑战性。在这里，我们报告了由酯酶激活生成羰基硫化物(COS)，并将其分解为H_2S的硫代甲氧基碳酸酯和硫代氨基甲酸酯。
Hydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S.