Functional MRI changes during panic anticipation and imagery exposure
Functional MRI changes during panic anticipation and imagery exposure
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DOI：
10.1097/00001756-200112210-00020
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发表时间：
2001-12-21
期刊：
影响因子：
1.7
通讯作者：
Bookheimer, SY
中科院分区：
文献类型：
--
作者：
Bystritsky, A;Pontillo, D;Bookheimer, SY
在接受功能磁共振检查时，6名被诊断为恐慌症的DSM IV患者和6名正常对照根据个人确定的行为等级，对中性、中度和高度焦虑的情况进行了直接成像。使用SPM99b对每组受试者在高度焦虑和中性焦虑状态下的大脑活动进行比较。恐慌症患者表现出额叶下部皮质、海马体和整个扣带回前部和后部的活动增加，延伸到眼眶前额叶皮质，并包围两个半球。这些区域可能构成了恐慌、混乱的精神病理中的重要回路。我们认为，这种活动模式可能会增强强烈情绪事件的编码和提取，促进创伤经历的重现，并导致脆弱个体的惊恐障碍。《神经报告》12：3953-3957(C)2001 Lippincott Williams&Wilkins.
While undergoing fMRI, six patients with DSM IV diagnosis of panic disorder and six normal controls performed directed imagery of neutral, moderate and high anxiety situations based on an individually determined behavioral hierarchy. Brain activity was compared during high vs neutral anxiety blocks for each group of subjects using SPM99b. Panic patients showed increased activity in inferior frontal cortex, hippocampus and throughout the cingulate both anterior and posterior, extending into the orbitofrontal cortex and encompassing both hemispheres. These areas may constitute the important circuit in the psychopathology of panic, disorder. We propose that this pattern of activity may enhance the encoding and retrieval of strong emotional events, facilitating the recapitulation of traumatic experiences and leading to panic disorder in vulnerable individuals. NeuroReport 12:3953-3957 (C) 2001 Lippincott Williams & Wilkins.