Vertex shedding as a precursor of turbulent electrical activity in cardiac muscle
Vertex shedding as a precursor of turbulent electrical activity in cardiac muscle
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DOI：
10.1016/s0006-3495(96)79691-1
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发表时间：
1996-03-01
影响因子：
3.4
通讯作者：
Jalife, J
中科院分区：
文献类型：
--
作者：
Cabo, C;Pertsov, AM;Jalife, J
在心脏组织中，在膜钠通道部分阻断期间，或在高频兴奋时，具有尖锐边缘的不可兴奋的障碍物可能破坏电激发波的传播，导致自持性涡旋和湍流心脏电活动的形成。利用电压敏感染料结合视频成像技术，在绵羊心外膜组织中观察到这种涡旋的形成，这种涡旋在视觉上类似于流体力学湍流中的涡旋脱落。涡流脱落是导致心脏失控高频兴奋自发启动的一种潜在机制。
In cardiac tissue, during partial blockade of the membrane sodium channels, or at high frequencies of excitation, inexcitable obstacles with sharp edges may destabilize the propagation of electrical excitation waves, causing the formation of self-sustained vortices and turbulent cardiac electrical activity, The formation of such vortices, which visually resembles vortex shedding in hydrodynamic turbulent flows, was observed in sheep epicardial tissue using voltage-sensitive dyes in combination with video-imaging techniques. Vortex shedding is a potential mechanism leading to the spontaneous initiation of uncontrolled high-frequency excitation of the heart.