Chronic oral arsenic intoxication as a possible aetiological factor in idiopathic portal hypertension (non-cirrhotic portal fibrosis) in India.
Chronic oral arsenic intoxication as a possible aetiological factor in idiopathic portal hypertension (non-cirrhotic portal fibrosis) in India.
复制标题
慢性口服砷中毒是印度特发性门静脉高压（非肝硬化门静脉纤维化）的可能病因。
作者：
D. V. Datta;S. Mitra;P. N. Chhuttani;R. Chakravarti
估计砷浓度的肝标本中9例特发性门脉高压症（IP），并在4个肝脏，这些被发现显着高于肝硬化患者和对照组。脾静脉造影显示广泛的门体侧支循环。校正的正弦压力和血流研究显示，四名患者的水平高于正常人。肝组织的显微镜检查显示门静脉周围纤维化。肝脏砷含量较高是由于无意中饮用了被砷污染的水，掺杂的鸦片和土着药物。没有提供鸦片摄入史，但有两名患者饮用了被砷污染的水，另外两名患者服用了bhasams（通过反复氧化矿石制备的阿育吠陀药物）。虽然特发性门脉高压症的病因尚不清楚，但砷摄入可能是其中一个因素。
Estimates were made of the arsenic concentration in liver specimens from nine patients having idiopathic portal hypertension (IP), and in four livers these were found to be significantly higher than those in patients with cirrhosis and in control subjects. The splenovenogram revealed extensive portosystemic collateral circulation. Corrected sinusoidal pressure and blood flow studies showed higher levels in four patients than in normal subjects. Microscopic examination of liver tissues revealed periportal fibrosis. The higher hepatic arsenic levels that were found were due to the inadvertent drinking of water contaminated with arsenic, adulterated opium, and indigenous medicines. A history of opium intake was not forthcoming but two patients had drunk water contaminated with arsenic and two others had taken bhasams (Ayurvedic medicines prepared by repeated oxidation of ores). Though the aetiology of idiopathic portal hypertension is not known, it is possible that arsenic intake may be one of the factors.