Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers
Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers
复制标题
DOI：
10.1097/qad.0b013e328358cc75
复制
发表时间：
2012-10-23
期刊：
影响因子：
3.8
通讯作者：
Addo, Marylyn M.
中科院分区：
文献类型：
--
作者：
Angin, Mathieu;King, Melanie;Addo, Marylyn M.
调节性T细胞（Tregs）是有效的免疫调节剂，但它们在HIV发病机制中的确切作用仍不完全清楚。迄今为止，大多数研究都集中在“大量”Treg种群的频率或表型上。然而，尽管在其他疾病中已经报道了抗原特异性treg，但迄今为止尚未描述HIV-1表位特异性treg。我们在此报告了首次在hiv -1感染个体中使用人白细胞抗原II类四聚体染色鉴定功能性hiv -1 gag特异性调节性T细胞。
Regulatory T cells (Tregs) are potent immune modulators, but their precise role in HIV pathogenesis remains incompletely understood. Most studies to date have focused on frequencies or phenotypes of 'bulk' Treg populations. However, although antigen-specific Tregs have been reported in other diseases, HIV-1 epitope-specific Tregs have not been described to date. We here report the first identification of functional HIV-1-Gag-specific regulatory T cells using human leukocyte antigen class II tetramer staining in HIV-1-infected individuals.