Brief chemotherapy (Stanford V) and adjuvant radiotherapy for bulky or advanced Hodgkin's disease: an update.

Brief chemotherapy (Stanford V) and adjuvant radiotherapy for bulky or advanced Hodgkin's disease: an update.
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短期化疗(斯坦福 V)和辅助放疗治疗大块或晚期霍奇金病:更新。

DOI:
10.1093/annonc/7.suppl_4.s105
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发表时间:
1996
期刊:
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子:
--
通讯作者:
Hoppe,RT
Hoppe,RT
中科院分区:
--
文献类型:
--
作者:
Horning,SJ;Rosenberg,SA;Hoppe,RT

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从1989年5月至1995年8月,94例既往未经治疗的霍奇金病II期伴巨大纵隔受累(n= 28)或III或IV期(n= 66)患者接受了简化的化疗方案,斯坦福大学V,±放疗(RT)。化疗每周一次,持续12周,然后对最初的巨大病变部位进行巩固性RT。中位随访时间为3年,精算6年生存率为93%,无进展率为89%。在28例II期巨大纵隔疾病患者中,没有复发或死亡。在66例III-IV期疾病患者中,发生了8例复发和3例死亡。简化的化疗方案斯坦福大学V联合RT对大体积、局限期和晚期HD具有良好的耐受性和高效治疗。降低烷化剂、多柔比星、博莱霉素的累积暴露量和限制使用放射治疗,预计将改善生育前景,降低继发性肿瘤和晚期心肺毒性的风险。
From May 1989 to August 1995, 94 previously untreated patients with Hodgkin's disease stage II with bulky mediastinal involvement (n= 28) or stage III or IV (n= 66) received an abbreviated chemotherapy regimen, Stanford V, ± radiotherapy (RT). Chemotherapy was given weekly for 12 weeks followed by consolidative RT to sites of initial bulky disease. With a median follow-up of 3 years, the actuarial 6-year survival is 93% and the freedom from progression is 89%. There have been no relapses or deaths among the 28 patients with stage II bulky mediastinal disease. Eight relapses and three deaths have occurred in the group of 66 patients with stage III–IV disease. The abbreviated chemotherapy regimen, Stanford V, in combination with RT is well tolerated and highly effective therapy for bulky, limited stage and advanced stage HD. Lower cumulative exposure to alkylating agents, doxorubicin, bleomycin and limited use of radiation is expected to improve the prospects for fertility and decrease the risks for second neoplasms and late cardiopulmonary toxicity.
霍奇金病伴有大量纵隔受累。
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