Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.
Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.
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T 细胞恶性肿瘤中 14q32.1 的异常涉及两个癌基因。
DOI：
10.1073/pnas.96.6.2949
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发表时间：
1999
影响因子：
11.1
通讯作者：
Croce,CM
中科院分区：
文献类型：
--
作者：
Pekarsky,Y;Hallas,C;Isobe,M;Russo,G;Croce,CM
人类染色体14q32.1上的tcl1癌基因参与了人类T细胞白血病的发展。它在这些白血病中的表达被14q32.1染色体易位和倒位激活。在这里，我们报道了tcl1基因家族新成员TCL1b的分离和表征，tcl1的着丝粒约为16 kb。1.2 kbtcl1bcdna编码一个14kda的128 aa蛋白，与Tcl1相似度为60%。tcl1和tcl1b基因的表达谱非常相似：这两个基因在正常骨髓和外周淋巴细胞中的表达水平都很低，但在T细胞白血病中通过14q32.1区域的重排被激活。因此，T细胞恶性肿瘤中14q32.1位点的易位和倒位涉及两种癌基因。
TheTCL1oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of theTCL1gene family,TCL1b,located ≈16 kb centromeric ofTCL1. The 1.2-kbTCL1bcDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles ofTCL1andTCL1bgenes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32.1 in T cell malignancies involve two oncogenes.