Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice.
Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice.
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作者：
Omacetaxine mepesuccinate (formerly homoharringtonine) is a molecule with a mechanism of action that is different from tyrosine kinase inhibitors and its activity in chronic myeloid leukemia (CML) seems to be independent of BCR-ABL mutation status. Using BCR-ABL-expressing myelogenous and lymphoid cell lines and mouse models of CML and B cell acute lymphoblastic leukemia (B-ALL) induced by wild type BCR-ABL or T315I mutant-BCR-ABL, we evaluated the inhibitory effects of omacetaxine on CML and B-ALL. We demonstrated that more than 90% of the leukemic stem cells were killed after treatment with omacetaxine in vitro. In contrast, less than 9% or 25% of the leukemic stem cells were killed after treating with imatinib or dasatinib, respectively. After 4 days of treatment of CML mice with omacetaxine, Gr-1+myeloid leukemia cells decreased in the peripheral blood of the treated CML mice. In the omacetaxine treated B-ALL mice, only 0.8% B220+leukemia cells were found in peripheral blood, compared with 34% B220+leukemia cells in the placebo group. Treatment with omacetaxine decreased the number of leukemia stem cells and prolonged survival of mice with BCR-ABL induced CML or B-ALL.
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影响因子：
20.3
作者：
Konig, Heiko;Holyoake, Tessa L.;Bhatia, Ravi
通讯作者：
Bhatia, Ravi
DOI：
10.1084/jem.189.9.1399
发表时间：
1999-05-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Li S;Ilaria RL Jr;Million RP;Daley GQ;Van Etten RA
通讯作者：
Van Etten RA
影响因子：
20.3
作者：
Peng, Cong;Brain, Julia;Li, Shaoguang
通讯作者：
Li, Shaoguang
影响因子：
20.3
作者：
Zhang, CC;Lodish, HF
通讯作者：
Lodish, HF
影响因子：
30.8
作者：
Hu, YG;Liu, YH;Li, SG
通讯作者：
Li, SG