Scleroderma: skin stiffness assessment using the stress-strain relationship under progressive suction.
Scleroderma: skin stiffness assessment using the stress-strain relationship under progressive suction.
复制标题
硬皮病：使用渐进吸力下的应力-应变关系评估皮肤硬度。
DOI：
--
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
C. Piérard‐franchimont
中科院分区：
文献类型：
--
作者：
G. Piérard;T. Hermanns‐Lê;C. Piérard‐franchimont
引言
有几种非侵入性生物测量方法可用于监测系统性硬皮病中的皮肤硬化情况。其中，皮肤弹性测量仪（Cutometer®）已被多个临床团队使用多年。
目的
重新审视硬皮病中真皮纤维网络的微观结构以及与粘弹性变化的关系。
方法
按照渐进应力 - 应变模式应用皮肤弹性测量仪（Cutometer®）所采用的吸力方法。
结果
该测试程序足够灵敏，能够记录肢端硬皮病的初始进展阶段。由此确定了四个阶段，包括：i) 初期，ii) 进展期，iii) 明显期，iv) 消退期肢端硬皮病。
结论
皮肤生物力学功能的非侵入性测定在常规临床实践和抗硬化药物研发中均具有相关性。它是对特定血清生物标志物测定的补充，但不能替代后者。
INTRODUCTION
A few non-invasive biometrological methods are available for monitoring skin stiffening in systemic scleroderma. Among them, the Cutometer® is used for years by several clinical teams.
OBJECTIVES
To revisit the microscopic structure of the dermal fibrous networks in scleroderma and the relationship with changes in viscoelasticity.
METHODS
The suction method delivered by the Cutometer® was applied following the progressive stress-vs-strain modality.
RESULTS
The test procedure was sensitive enough to document the initial progression steps of acroscleroderma. Four stages were thus identified including i) the incipient, ii) the progressive, iii) the overt, and iv) the regressive acroscleroderma.
CONCLUSION
The non-invasive determination of skin biomechanical functions is relevant both in routine clinical practice and in antisclerotic drug development. It is complementary although not a substitute for the determination of selected serum biomarkers.