High-density lipoprotein size distribution can differ between subjects with alcoholic and non-alcoholic fatty liver disease.
High-density lipoprotein size distribution can differ between subjects with alcoholic and non-alcoholic fatty liver disease.
复制标题
患有酒精性和非酒精性脂肪肝病的受试者之间的高密度脂蛋白大小分布可能不同。
DOI：
10.7754/clin.lab.2013.130228
复制
发表时间：
2014
影响因子：
0.7
通讯作者：
N. Sakane
中科院分区：
文献类型：
--
作者：
K. Tsuzaki;K. Kotani;Shinji Fujiwara;Y. Sano;N. Sakane
背景
虽然饮酒与高密度脂蛋白（HDL）-胆固醇（HDL-C）（一种心血管风险标志物）水平相关，但HDL大小分布尚未在酒精性脂肪性肝病（AFLD）和非酒精性脂肪性肝病（NAFLD）受试者中表征。
方法
本研究比较了在一般健康检查期间招募的AFLD（36名男性，年龄61 +/- 14）和NAFLD（35名男性，年龄65 +/- 13）受试者之间的HDL亚组分特征。采用Lipoprint系统对脂蛋白进行电泳分离，测定血清HDL亚组分。
结果
AFLD受试者的小尺寸HDL部分比例（6.6 ± 5.7%）显著高于NAFLD受试者（3.8 ± 4.9%，p = 0.029）。
结论
在日本一般人群中，观察到AFLD受试者中小尺寸HDL部分的百分比高于NAFLD受试者。HDL大小的差异是否与心血管临床表现有关，有待进一步研究。
BACKGROUND
While alcohol consumption is associated with levels of high-density lipoprotein (HDL)-cholesterol (HDL-C), a cardiovascular risk marker, HDL size distribution has yet to be characterized in subjects with alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD).
METHODS
The present study compared HDL subfractional characteristics between subjects with AFLD (36 men, age 61 +/- 14) and NAFLD (35 men, age 65 +/- 13), recruited during general health check-ups. Serum HDL subfractions were measured with the electrophoretic separation of lipoproteins employing the Lipoprint system.
RESULTS
The subjects with AFLD had a significantly greater proportion of small-sized HDL part (6.6 +/- 5.7%) than those with NAFLD (3.8 +/- 4.9%, p = 0.029).
CONCLUSIONS
More percentages of small-sized HDL part were observed in the subjects with AFLD than in those with NAFLD in Japanese general population. Whether the difference of HDL size is associated with cardiovascular manifestations should be studied further.