DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure
DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure
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DOI：
10.3109/13547500903137265
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发表时间：
2009-01-01
期刊：
影响因子：
2.6
通讯作者：
Mutch, Elaine
中科院分区：
文献类型：
--
作者：
Atherton, Kathryn M.;Williams, Faith M.;Mutch, Elaine
A study of horticultural farmers exposed to organophosphate pesticides (OPs) and controls investigated the relationships between OP exposure, DNA damage and oxidative stress. Blood acetylcholinesterase (AChE) and urinary dialkylphosphate (DAP) levels determined exposure and 8-hydroxy-2'-deoxyguanosine (8OHdG) indicated oxidative stress status. The farmers had approximately 30% lower AChE activity and increased DAP levels compared with the controls, reflecting moderate OP exposure. They had higher DNA damage than the controls and there was a significant positive relationship between DAP and DNA damage with greater than 95% power. The farmers also had a significant positive relationship between urinary DAP and 8OHdG levels.
