Diabetes and risk of prostate cancer in a prospective cohort of US men
Diabetes and risk of prostate cancer in a prospective cohort of US men
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DOI：
10.1093/aje/kwh334
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发表时间：
2005-01-15
影响因子：
5
通讯作者：
Calle, EE
中科院分区：
文献类型：
--
作者：
Rodriguez, C;Patel, AV;Calle, EE
先前的一项研究表明，糖尿病可能会降低前列腺癌的风险，但只有在糖尿病诊断后几年。作者在癌症预防研究II营养队列中研究了糖尿病诊断时间与男性前列腺癌风险的关系。研究参与者在1992年登记时填写了一份邮寄的问卷，其中包括糖尿病的信息，并在1997年和1999年进行了随访问卷调查。糖尿病的历史信息也可从1982年的既往研究中获得。截至2001年8月31日，作者记录了72,670名男性中的5,318例前列腺癌病例。考克斯比例风险模型的结果显示，糖尿病与前列腺癌的发病率较低相关（率比（RR）= 0.67，95%置信区间（CI）：0.60，0.75）。这种相关性在糖尿病诊断后的时间上存在显著差异（p < 0.0002）;在糖尿病诊断后的前3年内，前列腺癌的风险略有增加（RR = 1.23，95% CI：0.92，1.65），但在4年或更长时间前诊断的男性中，前列腺癌的风险降低（RR = 0.63，95% CI：0.56，0.71）。研究结果与糖尿病与前列腺癌风险降低相关的假设一致，但仅在糖尿病诊断后几年。
One previous study has suggested that diabetes may decrease risk of prostate cancer but only several years after diagnosis of diabetes. The authors examined the role of timing of diabetes diagnosis in relation to risk of prostate cancer among men in the Cancer Prevention Study II Nutrition Cohort. Participants in the study completed a mailed questionnaire including information on diabetes at enrollment in 1992 and at follow-up questionnaires in 1997 and 1999. Historical information on diabetes was also available from a previous study in 1982. The authors documented 5,318 cases of incident prostate cancer through August 31, 2001, among 72,670 men. Results from Cox proportional hazards models showed that diabetes was associated with a lower incidence of prostate cancer (rate ratio (RR) = 0.67, 95% confidence interval (CI): 0.60, 0.75). This association differed significantly by time since diagnosis of diabetes (p < 0.0002); risk of prostate cancer was slightly increased during the first 3 years after diagnosis of diabetes (RR = 1.23, 95% CI: 0.92, 1.65) but was reduced among men diagnosed 4 or more years before (RR = 0.63, 95% CI: 0.56, 0.71). Study results are consistent with the hypothesis that diabetes is associated with reduced risk of prostate cancer but only several years after diagnosis of diabetes.