Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir.
Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir.
复制标题
针对持续性人类免疫缺陷病毒库的细胞介导的免疫。
DOI：
10.1093/infdis/jix002
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Montaner,LuisJ
中科院分区：
文献类型：
--
作者：
Riley,JamesL;Montaner,LuisJ
有效清除病毒感染的细胞需要先天性免疫效应器和适应性免疫效应器的连续活性。在人类免疫缺陷病毒（HIV）感染中，自然诱导的细胞介导的免疫反应很少能根除感染。然而，如果要解决表位逃逸和缺乏持续效应记忆反应的问题，优化的免疫反应可能会被用于艾滋病毒治疗。在这里，我们回顾了领先的艾滋病毒治疗策略，这些策略在稳定抑制的抗逆转录病毒治疗受试者中利用细胞介导的艾滋病毒控制。我们专注于通过顺序激活重建的免疫系统来最大化目标识别和根除的策略，同时提供最佳的T细胞反应，可以消除储存库，并作为在缺乏抗逆转录病毒治疗（ART）的情况下维持控制HIV传播的手段。正如 ART 的发展所证明的那样，我们认为基于免疫的策略的组合将是细胞介导的 HIV 控制和根除的最佳途径。来自多项人体试点试验的现有数据已经确定了目标策略，这些策略可以通过将先天性和工程化 T 细胞反应结合起来，以测试 HIV 持续缓解和/或治愈，从而最大限度地提高抗病毒压力。
Effective clearance of virally infected cells requires the sequential activity of innate and adaptive immunity effectors. In human immunodeficiency virus (HIV) infection, naturally induced cell-mediated immune responses rarely eradicate infection. However, optimized immune responses could potentially be leveraged in HIV cure efforts if epitope escape and lack of sustained effector memory responses were to be addressed. Here we review leading HIV cure strategies that harness cell-mediated control against HIV in stably suppressed antiretroviral-treated subjects. We focus on strategies that may maximize target recognition and eradication by the sequential activation of a reconstituted immune system, together with delivery of optimal T-cell responses that can eliminate the reservoir and serve as means to maintain control of HIV spread in the absence of antiretroviral therapy (ART). As evidenced by the evolution of ART, we argue that a combination of immune-based strategies will be a superior path to cell-mediated HIV control and eradication. Available data from several human pilot trials already identify target strategies that may maximize antiviral pressure by joining innate and engineered T cell responses toward testing for sustained HIV remission and/or cure.