p53 immunoreactivity in astrocytomas and its relationship to survival.
p53 immunoreactivity in astrocytomas and its relationship to survival.
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星形细胞瘤中的 p53 免疫反应性及其与生存的关系。
DOI：
10.1080/02688699550041476
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发表时间：
1995
影响因子：
1.1
通讯作者：
L. R. Bridges
中科院分区：
文献类型：
--
作者：
S. Al;L. R. Bridges
p53是一种推定的肿瘤抑制基因，与多种人类恶性肿瘤有关。p53基因的突变导致更稳定的产物和细胞中p53蛋白的量增加。因此，与正常情况不同，突变的p53可以通过免疫组织化学检测到。我们用两种抗p53的抗体PAb 1801和PAb 421对74例星形细胞瘤的冰冻切片进行染色。总体而言，18/74（24%）的星形细胞瘤显示p53免疫反应。15/47例IV级（32%）为p53免疫阳性，3/16例III级（19%）、0/7例II级（0%）和0/4例I级星形细胞瘤（0%）为p53免疫阳性。这些发现与先前的研究一致，显示高级别p53免疫阳性肿瘤的数量相对多于低级别p53免疫阳性肿瘤。尽管我们发现不同级别的肿瘤在生存率上存在预期的差异，但p53免疫阳性和免疫阴性肿瘤之间的生存率没有显著差异（p > 0.1）。我们的结论是，虽然p53无疑发挥了重要作用的分子“链”，导致恶性星形细胞瘤，在肿瘤的可比等级，它似乎并不影响生存。
p53 is a putative tumour suppressor gene implicated in a wide range of human malignancies. Mutation of p53 gene results in a more stable product and increased quantities of p53 protein in the cell. Thus, unlike the normal situation, mutated p53 is detectable by immunohistochemistry. We stained frozen sections of 74 astrocytomas with two antibodies to p53, PAb 1801 and PAb 421. Overall 18/74 (24%) of astrocytomas showed p53 immunoreactivity. Fifteen of 47 (32%) grade IV were p53 immunopositive, as were 3/16 (19%) grade III, 0/7 (0%) grade II and 0/4 (0%) grade I astrocytomas. These findings are in agreement with previous studies in showing relatively greater numbers of high grade than low grade p53 immunopositive tumours. Although we found an expected difference in survival according to grade, there was no significant difference in survival (p > 0.1) between p53 immunopositive and immunonegative tumours. We conclude that, whilst p53 undoubtedly plays an important role in the molecular 'chain' leading to malignancy in some astrocytomas, within tumours of comparable grade it does not appear to influence survival.
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人类星形细胞瘤进展过程中 p53 突变和 17 号和 10 号染色体杂合性丧失。
影响因子：
11.2
作者：
Fults,D;Brockmeyer,D;Tullous,MW;Pedone,CA;Cawthon,RM
通讯作者：
Cawthon,RM
影响因子：
11.2
作者：
A. Deimling;R. Eibl;H. Ohgaki;D. Louis;K. Ammon;I. Petersen;I. Petersen;P. Kleihues;R. Chung;Otmar D. Wiestler;B. Seizinger
通讯作者：
A. Deimling;R. Eibl;H. Ohgaki;D. Louis;K. Ammon;I. Petersen;I. Petersen;P. Kleihues;R. Chung;Otmar D. Wiestler;B. Seizinger
影响因子：
56.9
作者：
BAKER, SJ;MARKOWITZ, S;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
DOI：
10.1073/pnas.87.16.6166
发表时间：
1990-08-01
影响因子：
11.1
作者：
MERCER, WE;SHIELDS, MT;ULLRICH, SJ
通讯作者：
ULLRICH, SJ