THIAZORIFAMYCINS .3. BIOSYNTHESIS OF RIFAMYCIN-P, RIFAMYCIN-Q AND RIFAMYCIN-VERDE, NOVEL METABOLITES FROM A MUTANT OF NOCARDIA-MEDITERRANEA
THIAZORIFAMYCINS .3. BIOSYNTHESIS OF RIFAMYCIN-P, RIFAMYCIN-Q AND RIFAMYCIN-VERDE, NOVEL METABOLITES FROM A MUTANT OF NOCARDIA-MEDITERRANEA
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DOI：
10.7164/antibiotics.33.842
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发表时间：
1980-01-01
影响因子：
3.3
通讯作者：
SARTORI, G
中科院分区：
文献类型：
--
作者：
CRICCHIO, R;ANTONINI, P;SARTORI, G
噻唑霉素衍生自利福霉素S和半胱氨酸;利福霉素P和Verde通过化学反应形成，而利福霉素Q的合成涉及强制性酶促辅助。所有抗生素都来自一个共同的6元前体，缺少半胱氨酸的C-1;利福霉素Verde的噻嗪-2-酮环保留了半胱氨酸的C-2和C-3，而利福霉素P和Q的噻唑环仅保留了C-2，C-3成为环外收缩C-3存在于利福霉素Q中，而不是P中。
The thiazorifamycins are derived from rifamycin S and cysteine; rifamycins P and Verde are formed by chemical reactions, while rifamycin Q synthesis involves obligatory enzymatic assistance. All antibiotics come from a common 6-member precursor lacking C-1 of cysteine; the thiazin-2-one ring of rifamycin Verde retains both C-2 and C-3 of cysteine, while the thiazole ring of rifamycins P and Q retains only C-2, C-3 becoming exocyclic in the ring-contraction C-3 is present in rifamycin Q but not in P.