Spatial navigation and causal analysis in a brain-based device modeling cortical-hippocampal interactions
Spatial navigation and causal analysis in a brain-based device modeling cortical-hippocampal interactions
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DOI：
10.1385/ni:3:3:197
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发表时间：
2005-01-01
期刊：
影响因子：
3
通讯作者：
Edelman, GM
中科院分区：
文献类型：
--
作者：
Krichmar, JL;Seth, AK;Edelman, GM
我们描述了达尔文X，一个物理设备，与一个真实的环境，其行为是由一个模拟的神经系统结合海马及其周围区域的详细解剖学和生理学方面的指导。这个基于大脑的设备整合了来自环境的线索，并解决了空间记忆任务。在其探索行为的海马区的模拟神经元单位的反应是在啮齿动物海马的位置细胞相媲美，并出现了相关的感觉线索在探索。为了确定不同的功能海马通路及其对行为的影响，我们采用了时间序列分析，区分休闲互动内和之间的模拟海马和新皮层区域，而该设备是从事空间记忆任务。我们的分析确定了不同的功能通路内的神经模拟，并提示新的预测的影响，穿孔路径，三突触环和海马-皮质相互作用的位置细胞的活动和行为在导航。此外，这种偶然的时间序列分析在一般的网络分析中可能是有用的。
We describe Darwin X, a physical device that interacts with a real environment, whose behavior is guided by a simulated nervous system incorporating aspects of the detailed anatomy and physiology of the hippocampus and its surrounding regions. This brain-based device integrates cues from its environment and solves a spatial memory task. The response of simulated neuronal units in the hippocampal areas during its exploratory behavior are comparable to place cells in the rodent hippocampus and emerged by associating sensory cues during exploration. To identify different functional hippocampal pathways and their influence on behavior, we employed a time series analysis that distinguishes casual interaction within and between simulated hippocampal and neocortical regions while the device is engaged in a spatial memory task. Our analysis identified different functional pathways within the neural simulation and prompts novel predictions about the influence of the perforant path, the trisynaptic loop and hippocampal-cortical interactions on place cell activity and behavior during navigation. Moreover, this casual time series analysis may be useful in analyzing networks in general.