Selective killing of ovarian cancer cells through induction of apoptosis by nonequilibrium atmospheric pressure plasma
Selective killing of ovarian cancer cells through induction of apoptosis by nonequilibrium atmospheric pressure plasma
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DOI：
10.1063/1.3694928
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发表时间：
2012-03-12
影响因子：
4
通讯作者：
Hori, Masaru
中科院分区：
文献类型：
--
作者：
Iseki, Sachiko;Nakamura, Kae;Hori, Masaru
用非平衡大气压等离子体（NEAPP）处理两个独立的卵巢癌细胞系和成纤维细胞对照。大多数卵巢癌细胞通过连续等离子体处理从培养皿上分离到皿上的单个点。体外细胞增殖试验表明，与成纤维细胞相比，等离子体处理显著降低了卵巢癌细胞的增殖率。流式细胞术和western blot分析表明，等离子体处理卵巢癌细胞可诱导细胞凋亡。NEAPP可能是治疗卵巢癌的一个有前途的工具。(C)2012年美国物理学会。[http：//dx.doi.org/10.1063/1.3694928]
Two independent ovarian cancer cell lines and fibroblast controls were treated with nonequilibrium atmospheric pressure plasma (NEAPP). Most ovarian cancer cells were detached from the culture dish by continuous plasma treatment to a single spot on the dish. Next, the plasma source was applied over the whole dish using a robot arm. In vitro cell proliferation assays showed that plasma treatments significantly decreased proliferation rates of ovarian cancer cells compared to fibroblast cells. Flow cytometry and western blot analysis showed that plasma treatment of ovarian cancer cells induced apoptosis. NEAPP could be a promising tool for therapy for ovarian cancers. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3694928]