The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans
The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans
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DOI：
10.1002/1873-3468.13197
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发表时间：
2018-08-01
期刊：
影响因子：
3.5
通讯作者：
Plaxton, William C.
中科院分区：
文献类型：
--
作者：
Fedosejevs, Eric T.;Feil, Regina;Plaxton, William C.
在植物中，海藻糖6-磷酸（T6 P）是一种关键的信号代谢产物，它既是蔗糖水平的信号调节剂，又是蔗糖水平的负反馈调节剂。T6 P感知和调节蔗糖的作用方式尚未完全了解。在这里，我们表明，蔗糖分解活性的RcSUS 1，占主导地位的蔗糖合成酶同工酶在发展中的蓖麻子，是变构抑制T6 P。T6 P对SUS的反馈抑制作用可能与调节异养植物组织中的库强度和蔗糖分解通量有关。
In plants, trehalose 6-phosphate (T6P) is a key signaling metabolite that functions as both a signal and negative feedback regulator of sucrose levels. The mode of action by which T6P senses and regulates sucrose is not fully understood. Here, we demonstrate that the sucrolytic activity of RcSUS1, the dominant sucrose synthase isozyme expressed in developing castor beans, is allosterically inhibited by T6P. The feedback inhibition of SUS by T6P may contribute to the control of sink strength and sucrolytic flux in heterotrophic plant tissues.