The importance of laminin 5 in the dermal-epidermal basement membrane
The importance of laminin 5 in the dermal-epidermal basement membrane
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DOI：
10.1016/s0923-1811(00)00142-0
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发表时间：
2000-12-01
影响因子：
4.6
通讯作者：
Burgeson, RE
中科院分区：
文献类型：
--
作者：
Nishiyama, T;Amano, S;Burgeson, RE
皮肤由两个主要层组成，即表皮和真皮，由基底膜隔开。通过基底膜的表皮-真皮沟通对皮肤的动态平衡非常重要。基底膜含有特殊的结构，称为锚定复合体，确保了这两个组织间连接和通讯的稳定性。锚定复合体中的蛋白质提供与角质形成细胞内的细胞骨架角蛋白和真皮结缔组织蛋白的连接。该复合体的关键成分之一是层粘连蛋白5，它是表皮细胞附着所必需的。采用体外皮肤等效模型和体内角质形成细胞移植模型，研究了层粘连蛋白5的生物学功能。层粘连蛋白5作为连接表皮基底细胞和真皮乳头的主要纽带，启动半桥粒的形成，为真皮提供稳定的附着。层粘连蛋白5还可以加速基底膜的组装，并可能促进受损皮肤的恢复。表皮-真皮交界处完整的基底膜对皮肤的稳定性是必不可少的。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
The skin consists of two main layers, epidermis and dermis, separated by the basement membrane. Epidermal-dermal communication through the basement membrane is important for skin homeostasis. The basement membrane contains specialized structures, called the anchoring complex, which ensure the stability of connection and communication between these two tissue compartments. The proteins within the anchoring complex provide links to both the intracellular cytoskeletal keratins in keratinocytes and connective tissue proteins of the dermis. One of the key components of the complex is laminin 5, which is essential to epidermal cell attachment. The biological function of laminin 5 has been investigated by using a skin equivalent model in vitro and during keratinocyte sheet grafting in vivo. As a major link between the epidermal basal cells and the papillary dermis, laminin 5 initiates hemidesmosome formation and provides stable attachment of the epidermis to the dermis. Laminin 5 also accelerates the assembly of basement membranes and may enhance the recovery of damaged skin. An intact basement membrane at the epidermal-dermal junction is essential to stability of the skin. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.