Expression of matrix metalloproteinase-2 and-9 in oral squamous cell carcinomas with regard to the metastatic potential
Expression of matrix metalloproteinase-2 and-9 in oral squamous cell carcinomas with regard to the metastatic potential
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DOI：
10.1016/s1368-8375(99)00088-3
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发表时间：
2000-03-01
期刊：
影响因子：
4.8
通讯作者：
Lim, CY
中科院分区：
文献类型：
--
作者：
Hong, SD;Hong, SP;Lim, CY
为了评估基质金属蛋白酶（MMPs）在预测口腔鳞状细胞癌（SCCs）转移潜能中的意义，我们通过免疫组织化学和明胶酶谱法比较了19例口腔鳞状细胞癌转移患者的MMP-2和-9表达与25例非转移患者的MMP-2和-9表达。免疫组化显示MMP-2表达升高与转移无显著相关性；然而，口腔SCCs中MMP-9表达的增加在有转移的口腔SCCs中具有统计学意义。无转移者占36.0%,P < 0.05)。明胶酶谱分析显示，在转移性和非转移性口服SCCs中，活化形式的MMP-2没有显著差异。另一方面，在转移性SCCs中，活化形式的MMP-9显著增加。这些结果表明，口腔SCCs表达MMP-2和-9，并且MMP-9在口腔SCCs向邻近组织转移中比MMP-2发挥更重要的作用。分析MMP-9的表达可能有助于预测口腔SCCs的转移潜力。(C) 2000 Elsevier Science Ltd.版权所有。
In order to evaluate the significance of matrix metalloproteinases (MMPs) in predicting the metastatic potential of oral squamous cell carcinomas (SCCs), we compared MMP-2 and -9 expression in 19 metastasizing oral SCCs with that in 25 non-metastasizing cases by immunohistochemistry and gelatin zymography. Immunohistochemistry showed that increased MMP-2 expression was not significantly related to metastasis; increased MMP-9 expression found in oral SCCs was, however, statistically significant (oral SCCs with metastasis. 73.7%, those without metastasis, 36.0%: P < 0.05). Gelatin zymography revealed no significant difference in the activated form of MMP-2 between metastasizing and non-metastasizing oral SCCs. In metastasizing SCCs, on the other hand, increases in the activated form of MMP-9 were significant. These results suggest that oral SCCs express MMP-2 and -9, and that MMP-9 slay play a mole important role than MMP-2 in the metastasis of oral SCCs to adjacent tissue. An analysis of MMP-9 expression may be useful for predicting the metastatic potential of oral SCCs. (C) 2000 Elsevier Science Ltd. All rights reserved.