CAROTID-SINUS BARORECEPTOR REFLEX CONTROL OF RESPIRATION
CAROTID-SINUS BARORECEPTOR REFLEX CONTROL OF RESPIRATION
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DOI：
10.1161/01.res.51.5.624
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发表时间：
1982-01-01
影响因子：
20.1
通讯作者：
SHOUKAS, AA
中科院分区：
文献类型：
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作者：
BRUNNER, MJ;SUSSMAN, MS;SHOUKAS, AA
在10只切断迷走神经、自主呼吸、戊巴比妥麻醉的狗上研究了颈动脉窦压力感受性反射对呼吸的影响。通过手术将颈动脉体从颈动脉窦压力感受器区中切除，消除颈动脉体化学感受器反射反应。稳态频率，潮气量和每分钟通气量进行了测量后，25毫米汞柱的步骤变化，窦内压力之间的50和200毫米汞柱。在此范围内，窦内压力的逐步降低导致平均动脉压从86 mmHg增加到182 mmHg。呼吸反应曲线均呈S形。将窦内压从200 mm Hg降至50 mm Hg，导致呼吸频率从4.8次/min增至9.7次/min，潮气量从704 ml降至515 ml。计算的总通气量从3180 ml/min增加到4530 ml/min，吸气时间从3.7 s减少到2.4 s，呼气时间从9.8 s减少到4.1 s。这些反射反应是压力感受器反射介导的，而不是继发于动脉压的变化。显然，颈动脉窦压力感受性反射不仅控制动脉压，而且还通过呼吸频率和潮气量的变化同时影响通气。
The effect of the carotid sinus baroreceptor reflex on respiration was studied in 10 vagotomized, spontaneously breathing, pentobarbital-anesthetized dogs. The carotid body chemoreceptor reflex response was eliminated by surgically excluding the carotid bodies from the carotid sinus baroreceptor area. Steady-state frequency, tidal volume and minute ventilation were measured after 25-mm Hg step changes in intrasinus pressure between 50 and 200 mm Hg. Over this range, the step decreases in intrasinus pressure caused concomitant increases in mean arterial pressure from 86 to 182 mm Hg. All of the respiratory response curves were sigmoidal in shape. Decreasing intrasinus pressure from 200 to 50 mm Hg caused respiratory frequency to increase from 4.8 to 9.7/min and tidal volume to decrease from 704 to 515 ml. The calculated total ventilation increased from 3180 to 4530 ml/min. The time of inspiration decreased from 3.7 to 2.4 s, and the time of expiration decreased from 9.8 to 4.1 s. These ventilatory responses are baroreceptor reflex-mediated, and not secondary to changes in arterial pressure. Apparently, not only does the carotid sinus baroreceptor reflex control arterial pressure, but it also simutaneously influences ventilation, through changes in both respiratory frequency and tidal volume.