In vitro and in vivo activities of tea catechins against Helicobacter pylori
In vitro and in vivo activities of tea catechins against Helicobacter pylori
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DOI：
10.1128/aac.43.7.1788
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发表时间：
1999-07-01
影响因子：
4.9
通讯作者：
Takahashi, T
中科院分区：
文献类型：
--
作者：
Mabe, K;Yamada, M;Takahashi, T
儿茶素表没食子儿茶素没食子酸酯显示出测试的六种茶儿茶素中抗幽门螺杆菌的最强活性（50%测试菌株的MIC，8 μ g/ml）。它在pH 7时具有杀菌活性，但在pH小于或等于5.0时不具有杀菌活性。在感染的蒙古沙鼠中，H.在儿茶素处理的动物中，10 - 36%的幽门被根除，粘膜出血和糜烂显著减少。因此，茶儿茶素可能对H。幽门感染
The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 mu g/ml). It had bactericidal activity at pH 7 but not at pH less than or equal to 5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.