Exercise After Traumatic Brain Injury: Is it a Double-Edged Sword?
Exercise After Traumatic Brain Injury: Is it a Double-Edged Sword?
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DOI：
10.1016/j.pmrj.2011.02.008
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发表时间：
2011-06-01
期刊：
影响因子：
2.1
通讯作者：
Griesbach, Grace S.
中科院分区：
文献类型：
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作者：
Griesbach, Grace S.
本文描述了运动对创伤性脑损伤 (TBI) 后神经可塑性的影响。有强有力的证据表明，运动通过激活特定的神经元回路和增加增强突触可塑性的分子来具有神经保护作用。讨论了从 TBI 实验模型中获得的结果，以支持使用运动作为康复工具。这些研究表明，损伤特征可能会影响治疗性运动的时间窗口。人类和动物研究的结果表明，过早的脑震荡后运动可能会加剧脑震荡后症状并破坏恢复过程，从而有害。更好地了解 TBI 后影响运动的机制将有助于改进恢复运动活动的指南以及成功地将运动用作治疗工具。 PM R 2011；3：S64-S72
This article describes the effects of exercise on neural plasticity after traumatic brain injury (TBI). There is strong evidence that indicates that exercise has neuroprotective effects by activating specific neuronal circuits and increasing molecules that enhance synaptic plasticity. Findings obtained from experimental models of TBI are discussed to support the use of exercise as a rehabilitative tool. These studies indicate that injury characteristics are likely to influence the time window for therapeutic exercise. Results of human and animal studies suggest that premature postconcussive exercise may be deleterious by exacerbating postconcussive symptomatology and disrupting restorative processes. A better understanding of the mechanisms that influence exercise after TBI will contribute to improving guidelines for the return to exercise activities and to the successful use of exercise as a therapeutic tool. PM R 2011;3:S64-S72