Elevated brain scyllo-inositol concentrations in patients with Alzheimer's disease
Elevated brain scyllo-inositol concentrations in patients with Alzheimer's disease
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DOI：
10.1002/nbm.1132
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发表时间：
2007-12-01
影响因子：
2.9
通讯作者：
Marson, Daniel C.
中科院分区：
文献类型：
--
作者：
Griffith, H. Randall;den Hollander, Jan A.;Marson, Daniel C.
体内 H-1 MRS 显示轻度阿尔茨海默病 (AD) 患者和遗忘性轻度认知障碍 (MCI) 患者中 N-乙酰天冬氨酸 (NAA) 减少，肌醇 (mI) 升高。我们不知道有研究记录了 AD 患者或 MCI 患者的鲨肌醇 (sI) 水平异常，尽管之前针对老年人的 MRS 研究表明 sI 是 AD 中值得测量的峰值。本研究招募了 15 名轻度 AD 患者、26 名遗忘性 MCI 患者和 19 名健康老年人。所有患者均使用 3 T MRI 扫描仪对大脑后扣带回进行 1 H MRS。轻度 AD 患者的 sI/肌酸 (Cr) 比值有所增加 (P < 0.05)。轻度AD（P < 0.01）和MCI（P < 0.05）患者的mI/Cr比值升高。轻度 AD 患者的 NAA/Cr 降低（P < 0.05）。 sI/Cr 比值与轻度 AD 患者的时钟绘制测量值呈负相关（r = -0.60，P < 0.05），表明 AD 患者认知能力受损与较高浓度的 sI/Cr 相关。对轻度 AD 患者后扣带回 sI/Cr 的体内测量显示，与认知健康的老年人相比，sI/Cr 有所增加。需要进一步研究 AD 中 sI 增加的机制。未来对 MCI 和 AD 中 sI/Cr 纵向过程的研究似乎是有必要的。版权所有 (c) 2007 John Wiley & Sons, Ltd.
In vivo H-1 MRS reveals reduced N-acetylaspartate (NAA) and elevated inyo-inositol (mI) in patients with mild Alzheimer's disease (AD) and patients with amnestic mild cognitive impairment (MCI). We are unaware of studies that have documented abnormal scyllo-inositol (sI) levels in patients with AD or patients with MCI, although a previous MRS study in older adults has indicated that sI is a peak of interest to measure in AD. Fifteen patients with mild AD, 26 patients with amnestic MCI, and 19 healthy older adults were recruited to this study. All underwent 1H MRS of the posterior cingulate gyrus of the brain using a 3 T MRI scanner. Increases in the sI/creatine (Cr) ratio were observed in patients with mild AD (P < 0.05). The mI/Cr ratio was raised in patients with mild AD (P < 0.01) and MCI (P < 0.05). Reduced NAA/Cr was detected in patients with mild AD (P < 0.05). The sI/Cr ratio correlated negatively (r = -0.60, P < 0.05) with a measure of clock drawing in patients with mild AD, indicating that impaired cognitive ability in AD is associated with higher concentrations of sI/Cr. In vivo measurement of sI/Cr in the posterior cingulate gyrus of patients with mild AD revealed increases compared with cognitively healthy older adults. Further research on the mechanisms of sI increase in AD is needed. Future studies on the longitudinal course of sI/Cr in MCI and AD appear warranted. Copyright (c) 2007 John Wiley & Sons, Ltd.