Resting State Default Mode Network Connectivity, Dual Task Performance, Gait Speed, and Postural Sway in Older Adults with Mild Cognitive Impairment.
Resting State Default Mode Network Connectivity, Dual Task Performance, Gait Speed, and Postural Sway in Older Adults with Mild Cognitive Impairment.
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DOI：
10.3389/fnagi.2017.00423
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发表时间：
2017
影响因子：
4.8
通讯作者：
Liu-Ambrose T
中科院分区：
文献类型：
--
作者：
Crockett RA;Hsu CL;Best JR;Liu-Ambrose T
衰老与跌倒风险增加有关。特别是，与健康的老年人相比，患有轻度认知障碍（MCI）的老年人更容易跌倒。导致跌倒风险增加的主要原因包括双重任务表现、步态速度和姿势摇摆的下降。最近的证据强调了默认模式网络（DMN）、额顶叶网络（FPN）和辅助运动区（SMA）对双重任务表现、步态速度和姿势摇摆的潜在影响。 DMN 在休息时活跃，在面向任务的过程中停用，以保持注意力并专注于任务。 FPN 和 SMA 参与自上而下的注意力控制、运动规划和运动执行。在患有 MCI 的老年人中，DMN 在任务期间表现出较少的失活。从理论上讲，这种缺乏失活的情况会增加 DMN 和与任务相关的大脑区域（例如 FPN 和 SMA）之间的资源竞争，从而增加对任务的注意力分散并降低任务绩效。然而，尚未有研究调查 DMN 与这些区域的网络间连接与双重任务行走、步态速度或姿势摇摆之间的关系。我们假设，DMN 内部以及 DMN-FPN 和 DMN-SMA 之间的功能连接性更强，与患有 MCI 的老年人在双任务步行过程中表现较差、步态速度较慢以及姿势摇摆较大有关。对 40 名患有 MCI 的老年人进行了双重任务步行模式、4 米步行的步态速度以及使用摇摆仪的姿势摇摆测量。 DMN 内更大的连接性与较差的双重任务性能显着相关。此外，DMN 和 SMA 之间更大的网络间连接与较慢的步态速度和睁眼地板摇摆任务中更大的姿势摇摆显着相关。因此，更大的静息状态 DMN 功能连接可能是导致双重任务能力降低、步态速度减慢和姿势摇摆更大的潜在神经机制，导致患有 MCI 的老年人行动障碍和跌倒的风险增加。
Aging is associated with an increased risk of falling. In particular, older adults with mild cognitive impairment (MCI) are more vulnerable to falling compared with their healthy counterparts. Major contributors to this increased falls risk include a decline in dual task performance, gait speed, and postural sway. Recent evidence highlights the potential influence of the default mode network (DMN), the frontoparietal network (FPN), and the supplementary motor area (SMA) on dual task performance, gait speed, and postural sway. The DMN is active during rest and deactivates during task-oriented processes, to maintain attention and stay on task. The FPN and SMA are involved in top-down attentional control, motor planning, and motor execution. The DMN shows less deactivation during task in older adults with MCI. This lack of deactivation is theorized to increase competition for resources between the DMN and task-related brain regions (e.g., the FPN and SMA), increasing distraction from the task and reducing task performance. However, no study has yet investigated the relationship between the between-network connectivity of the DMN with these regions and dual task walking, gait speed or postural sway. We hypothesized that greater functional connectivity both within the DMN and between DMN–FPN and DMN–SMA, will be associated with poorer performance during dual task walking, slower gait speed, and greater postural sway in older adults with MCI. Forty older adults with MCI were measured on a dual task-walking paradigm, gait speed over a 4-m walk, and postural sway using a sway-meter. Greater within-DMN connectivity was significantly correlated with poorer dual task performance. Furthermore, greater inter-network connectivity between the DMN and SMA was significantly correlated with slower gait speed and greater postural sway on the eyes open floor sway task. Thus, greater resting state DMN functional connectivity may be an underlying neural mechanism for reduced dual task ability, slower gait speed, and greater postural sway, resulting in the increased risk of mobility disability and falling in older adults with MCI.
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DOI：
10.1016/j.jalz.2013.02.007
发表时间：
2014-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Gifford KA;Liu D;Lu Z;Tripodis Y;Cantwell NG;Palmisano J;Kowall N;Jefferson AL
通讯作者：
Jefferson AL
影响因子：
3.1
作者：
Beurskens R;Bock O
通讯作者：
Bock O
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
1.8
作者：
Lajoie, Y;Teasdale, N;Fleury, M
通讯作者：
Fleury, M