District Differences in the Measured Values of Arterial Stiffness in Japan.
District Differences in the Measured Values of Arterial Stiffness in Japan.
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DOI：
10.1253/circrep.cr-21-0064
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发表时间：
2021-10-08
期刊：
影响因子：
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通讯作者：
Arita M
中科院分区：
文献类型：
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作者：
Miyai N;Uchiba K;Tomiyama H;Matsumoto C;Kinoshita A;Vlachoupolos C;Nilsson PM;Arita M
背景：在日本，心血管疾病（CVD）患病率的地区差异是众所周知的。这项研究调查了日本地区动脉硬度测量值的差异，动脉硬度是心血管疾病的独立危险因素。方法与结果：2018年在和歌山县（n=461）和长野县（n=186）参加健康检查的当地居民被招募到研究中。评估肱-踝脉波速度（baPWV）作为动脉僵硬度的指标。多因素调整后，和歌山地区≥70岁受试者的baPWV显著高于长野地区（平均[±SE] 1,912±25 vs. 1,763±30 cm/s； P<0.01），而<70岁受试者的baPWV无显著差异。多元线性回归分析表明，和歌山/长野地区差异与baPWV显著相关（P<0.01）。结论：和歌山和长野的动脉硬度测量值存在地区差异。和歌山县和长野县分别是日本心血管疾病患病率较高和较低的代表性地区。因此，基于本研究的结果，我们建议开展一项研究，以检查动脉硬度的地区差异是否导致CVD患病率的地区差异。
Background: In Japan, district differences in the prevalence of cardiovascular disease (CVD) are well-known. This study examined district differences in Japan in measured values of arterial stiffness, an independent risk factor for CVD. Methods and Results: Local residents participating in health checkups conducted in the Wakayama (n=461) and Nagano (n=186) prefectures in 2018 were recruited to the study. Brachial-ankle pulse wave velocity (baPWV) was evaluated as an index of arterial stiffness. After multivariate adjustment, baPWV was significantly higher in the Wakayama than Nagano district in subjects aged ≥70 years (mean [±SE] 1,912±25 vs. 1,763±30 cm/s; P<0.01), but not in subjects aged <70 years. Multivariate linear regression analysis demonstrated that the Wakayama/Nagano district difference was significantly (P<0.01) associated with baPWV. Conclusions: District differences were observed in the measured values of arterial stiffness in Wakayama and Nagano. The Wakayama and Nagano prefectures are representative areas with a relatively high and relatively low prevalence of CVD, respectively, in Japan. Therefore, based on the results of the present study, we propose to conduct a study to examine whether district differences in arterial stiffness underlie district differences in the prevalence of CVD.