Preliminary Observation of Dynamic Changes in Alcohol Concentration in the Human Brain with Proton Magnetic Resonance Spectroscopy on a 3T MR Instrument
Preliminary Observation of Dynamic Changes in Alcohol Concentration in the Human Brain with Proton Magnetic Resonance Spectroscopy on a 3T MR Instrument
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DOI：
10.2463/mrms.2012-0056
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发表时间：
2013-01-01
影响因子：
3
通讯作者：
Otsuka, Hideki
中科院分区：
文献类型：
--
作者：
Kubo, Hitoshi;Harada, Masafumi;Otsuka, Hideki
目的：我们的目的是建立合适的条件质子磁共振波谱（MRS）来测量酒精浓度在人脑中的动态变化，以评估这些变化，并比较结果与分析的呼吸蒸汽和血液samples.Materials和方法的数据：我们评估了4名健康志愿者（平均年龄26.5岁，3名男性，一名女性），没有神经系统的结果。所有研究均使用3特斯拉临床设备和8通道头部线圈进行。我们应用了我们修改后的单体素点分辨光谱（PRESS）序列。在受试者饮酒和便餐之前和之后，对MRS、呼吸蒸汽和血液样本进行连续测量。通过LC Model Ver. 6.1，和MRS测量的准确性估计使用估计的标准偏差表示的百分比（%SD）作为criterion.Results：饮酒后的酒精峰值清楚地检测到在1.2 ppm的所有测量持续时间。亚分钟MRS测量发现呼吸蒸汽或血液样本与MRS之间具有良好的相关性。连续测量表明，酒精在大脑中的时间依赖性变化和不同的subjects.Conclusions：临床3T设备，使直接评价亚分钟的变化，在人类大脑中的酒精代谢。
Purpose: Our purposes were to establish suitable conditions for proton magnetic resonance spectroscopy (MRS) to measure dynamic changes in alcohol concentration in the human brain, to evaluate these changes, and to compare the findings with data from analysis of breath vapor and blood samples.Materials and Methods: We evaluated 4 healthy volunteers (mean age 26.5 years; 3 males, one female) with no neurological findings. All studies were performed with 3-tesla clinical equipment using an 8-channel head coil. We applied our modified single-voxel point-resolved spectroscopy (PRESS) sequence. Continuous measurements of MRS, breath vapor, and blood samples were conducted before and after the subjects drank alcohol with a light meal. The obtained spectra were quantified by LCModel Ver. 6.1, and the accuracy of the MRS measurements was estimated using the estimated standard deviation expressed in percentage (%SD) as a criterion.Results: Alcohol peaks after drinking were clearly detected at 1.2 ppm for all durations of measurement. Good correlations between breath vapor or blood sample and MRS were found by sub-minute MRS measurement. The continuous measurement showed time-dependent changes in alcohol in the brain and various patterns that differed among subjects.Conclusions: The clinical 3T equipment enables direct evaluation of sub-minute changes in alcohol metabolism in the human brain.