Target localization and real-time tracking using the calypso 4D localization system in patients with localized prostate cancer
Target localization and real-time tracking using the calypso 4D localization system in patients with localized prostate cancer
复制标题
DOI：
10.1016/j.ijrobp.2006.01.050
复制
发表时间：
2006-06-01
影响因子：
7
通讯作者：
Sandler, Howard M.
中科院分区：
文献类型：
--
作者：
Willoughby, Twyla R.;Kupelian, Patrick A.;Sandler, Howard M.
目的：正在开发Calypso 4D定位系统，以在放射治疗期间提供准确、精确、客观和连续的靶定位。这项研究涉及第一个人类使用的系统，以评估这种技术的定位精度与放射定位，并评估其能力，以获得实时前列腺运动information.Methods和材料：三个转发器植入在每个20例患者。20例患者中的11例合格患者参加了一个研究组，该研究组比较了射线照相三角定位的应答器位置与电磁记录的应答器位置。应答器被跟踪了8分钟periods.Results：所有的复苏都是成功的，没有重大并发症。转发器之间的距离基本稳定。根据Calypso系统的应答器位置对患者定位与放射学应答器定位的比较显示，平均（+/-SD）3D差异为1.5 +/-0.9 mm。在8 min的跟踪过程中，11名患者中有2名显示出明显的器官运动（> 1 cm），有些运动持续时间超过1 min。Calypso应答器可用作前列腺内磁性基准点。这种新型的4D非电离电磁定位系统与转发器的临床评价表明，与X射线定位相比，定位精度相当的等中心点（2 mm内）。(c)2006年爱思唯尔公司
Purpose: The Calypso 4D Localization System is being developed to provide accurate, precise, objective, and continuous target localization during radiotherapy. This study involves the first human use of the system, to evaluate the localization accuracy of this technique compared with radiographic localization and to assess its ability to obtain real-time prostate-motion information.Methods and Materials: Three transponders were implanted in each of 20 patients. Eleven eligible patients of the 20 patients participated in a study arm that compared radiographic triangulated transponder locations to electromagnetically recorded transponder locations. Transponders were tracked for 8-min periods.Results: The implantations were all successful, with no major complications. Intertransponder distances were largely stable. Comparison of the patient localization on the basis of transponder locations as per the Calypso system with the radiographic transponder localization showed an average (+/- SD) 3D difference of 1.5 +/- 0.9 mm. Upon tracking during 8 min, 2 of the 11 patients showed significant organ motion (> 1 cm), with some motion lasting longer that 1 min.Conclusion: Calypso transponders can be used as magnetic intraprostatic fiducials. Clinical evaluation of this novel 4D nonionizing electromagnetic localization system with transponders indicates a comparable localization accuracy to isocenter, (within 2 mm) compared with X-ray localization. (c) 2006 Elsevier Inc.