Addition of N-carbobenzyloxy-L-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine.
Addition of N-carbobenzyloxy-L-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine.
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DOI：
10.1016/j.chroma.2008.01.059
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发表时间：
2008-03
期刊：
影响因子：
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通讯作者：
J. Haginaka;Aya Futagami
中科院分区：
文献类型：
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作者：
J. Haginaka;Aya Futagami
以4-乙烯基吡啶为功能单体，甲苯/1-十二烷醇为致孔剂，制备了（+）-尼伐地平的分子印迹聚合物（MIP）整体柱。以（+）-尼伐地平为单一模板分子制备的MIP整体柱没有大的通孔，而以Cbz-l-Trp为共模板分子则可以形成大的通孔。此外，前者尼伐地平对映体不能分离，但后者可以。Cbz-l-Trp的存在影响聚合过程，导致（+）-尼伐地平分子印迹整体柱形成大孔，实现尼伐地平对映体的分离。这些结果表明，Cbz-l-Trp的共加成可以有效地制备用于制备困难的（+）-尼伐地平的MIP整体料。
Molecularly imprinted polymer (MIP) monoliths for (+)-nilvadipine have been prepared using 4-vinylpyridine as a functional monomer and toluene/1-dodecanol as a porogen without or with addition of N-carbobenzyloxy-l-tryptophan (Cbz-l-Trp) as a co-template molecule. The MIP monoliths prepared with (+)-nilvadipine as a sole template molecule had no macro through-pores, while those could be formed by addition of Cbz-l-Trp as the co-template molecule. Furthermore, on the former nilvadipine enantiomers could not be separated, but on the latter they could. The presence of Cbz-l-Trp affected the polymerization process and resulted in forming macro through-pores of the MIP monoliths for (+)-nilvadipine and attaining separation of nilvadipine enantiomers. These results suggest that co-addition of Cbz-l-Trp could be effective for preparing MIP monoliths for (+)-nilvadipine, whose preparation is difficult.