Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy
Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy
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DOI：
10.1037/1064-1297.6.3.331
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发表时间：
1998-08-01
影响因子：
2.3
通讯作者：
Westman, EC
中科院分区：
文献类型：
--
作者：
Rose, JE;Behm, FM;Westman, EC
尼古丁拮抗剂美加明在一项随机戒烟试验中进行了评估。四组参与者（每组n = 20）在戒烟前接受尼古丁加美加明、单独尼古丁、单独美加明或无药物治疗4周。戒烟后，所有受试者均接受尼古丁+美卡拉明治疗6周。使用尼古丁皮肤贴剂（21 mg/24 hr）和美加明胶囊（2.5-5.0 mg，每日两次）。预处理美加明显著延长了持续戒烟的持续时间;治疗结束时，美加明组的戒烟率为47.5%，未加美加明组为27.5%。尼古丁+美卡拉明比单独使用任何一种药物都更能减少随意吸烟、吸烟满意度和烟瘾。此外，美加明引起的直立性血压下降被尼古丁抵消。戒烟前使用美加明可能是尼古丁贴片治疗的有效辅助手段。
The nicotinic antagonist mecamylamine was evaluated in a randomized smoking cessation trial. Four groups of participants (n = 20 per group) received nicotine plus mecamylamine, nicotine alone, mecamylamine alone, or no drug for 4 weeks before cessation. After the quit-smoking date, all subjects received nicotine plus mecamylamine treatment for 6 weeks. Nicotine skin patches (21 mg/24 hr) and mecamylamine capsules (2.5-5.0 mg twice per day) were used. Precessation mecamylamine significantly prolonged the duration of continuous smoking abstinence; abstinence rates at the end of treatment were 47.5% with mecamylamine and 27.5% without mecamylamine. Nicotine + mecamylamine reduced ad lib smoking, smoking satisfaction, and craving more than either drug alone. Moreover, the orthostatic decrease in blood pressure caused by mecamylamine was offset by nicotine. Mecamylamine before smoking cessation may be an effective adjunct to nicotine patch therapy.