What level of IBS symptoms drives impairment in health-related quality of life in community subjects with irritable bowel syndrome? Are current IBS symptom thresholds clinically meaningful?
What level of IBS symptoms drives impairment in health-related quality of life in community subjects with irritable bowel syndrome? Are current IBS symptom thresholds clinically meaningful?
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DOI：
10.1007/s11136-011-9985-5
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发表时间：
2012-06-01
影响因子：
3.5
通讯作者：
Talley, Nicholas J.
中科院分区：
文献类型：
--
作者：
Koloski, Natasha A.;Boyce, Philip M.;Talley, Nicholas J.
Background Quality of life is impaired in some people with IBS, but the level of symptoms that may drive this impairment is unclear.Aims We aimed to identify whether current frequency and severity cut-offs for IBS-type symptoms are associated with a clinically meaningful impairment of quality of life in the community.Methods People who met modified Rome III criteria for IBS (n = 201) and controls (n = 1,904) were assessed. Frequency of IBS symptoms was grouped a priori into 'less frequent' (not at all and sometimes) and 'more' frequent (often, very often and almost always). Severity of abdominal pain was grouped into 'mild' (very mild and mild) and severe (moderate, severe and very severe). Mental and physical functioning was measured using the valid SF-12, with 'normal' functioning (defined as a score of >43 and >48) and 'impaired' functioning (defined as a score of
