Native functionality and therapeutic targeting of arenaviral glycoproteins.
Native functionality and therapeutic targeting of arenaviral glycoproteins.
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DOI：
10.1016/j.coviro.2016.04.001
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发表时间：
2016-06
影响因子：
5.9
通讯作者：
Bowden TA
中科院分区：
文献类型：
--
作者：
Crispin M;Zeltina A;Zitzmann N;Bowden TA
表面糖蛋白直接沙粒病毒的细胞靶向、附着和膜融合，是中和抗体的主要目标。尽管沙粒病毒家族的糖蛋白结构具有显著的保守性，但在宿主细胞进入过程中使用的分子识别机制存在相当大的差异。我们回顾了这些感染事件的最新研究进展，并描述了小分子抗病毒药物、自然免疫反应和基于免疫球蛋白的治疗方法如何靶向沙粒病毒糖蛋白。沙粒病毒糖蛋白介导的组装和感染途径为治疗干预提供了许多机会和挑战。
Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralising antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivirals, the natural immune response and immunoglobulin-based therapeutics. Arenaviral glycoprotein-mediated assembly and infection pathways present numerous opportunities and challenges for therapeutic intervention.