A prospective study of cigarette smoking and age-related macular degeneration in women
A prospective study of cigarette smoking and age-related macular degeneration in women
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DOI：
10.1001/jama.276.14.1141
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发表时间：
1996-10-09
影响因子：
120.7
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
--
作者：
Seddon, JM;Willett, WC;Hankinson, SE
目标。目的：评价吸烟与女性年龄相关性黄斑变性（AMD）发病率之间的关系。-前瞻性队列研究，随访12年（1980 - 1992），每2年更新一次吸烟习惯信息。-美国11个州，参与者。一共有31843名注册护士参加了护士健康研究，这些护士在1980年年龄在50到59岁之间，在研究开始时没有报告癌症或AMD的诊断。其他女性在50岁时加入了分析队列。主要结果测量。- AMD伴视力丧失的发生率。在556338人年的随访中，215名女性被新诊断为AMD。在调整了AMD的其他危险因素后，与从不吸烟的女性相比，目前每天吸烟25支或更多的女性AMD的相对风险（RR）为2.4（95%可信区间[CI]， 1.4-4.0）。与从不吸烟者相比，曾经吸烟的人患肺癌的风险也增加了2倍（RR=2.0; 95% CI, 1.2-3.4）。与当前吸烟者相比，即使在戒烟15年或更长时间后，风险也没有降低。患AMD的风险也随着吸烟年数的增加而增加（P为趋势）
Objective.-To evaluate the relationship between cigarette smoking acid incidence of age-related macular degeneration (AMD) among women.Design.-Prospective cohort study with 12 years of follow-up (1980 to 1992), in which information on smoking habits was updated every 2 years.Setting.-Eleven states throughout the United States.Participants.-A total of 31 843 registered nurses enrolled in the Nurses' Health Study who were aged 50 to 59 years in 1980 and did not report a diagnosis of cancer or AMD at the beginning of the study. Additional women entered the analytic cohort as they reached 50 years of age.Main Outcome Measure.-Incidence of AMD with visual loss.Results.-During 556 338 person-years of follow-up, 215 women were newly diagnosed as having AMD. After adjusting for other risk factors for AMD, women who currently smoked 25 or more cigarettes per day had a relative risk (RR) of AMD of 2.4 (95% confidence interval [CI], 1.4-4.0) compared with women who never smoked. Past smokers of this amount also had a 2-fold increased risk (RR=2.0; 95% CI, 1.2-3.4) relative to never smokers. Compared with current smokers, little reduction in risk was suggested even after quitting smoking for 15 or more years. Risk of AMD also increased with an increasing number of pack-years smoked (P for trend